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Urinary monocyte chemotactic protein-1 (MCP-1) in leprosy patients: increased risk for kidney damage

BACKGROUND: We aimed to evaluate urinary MCP-1 and oxidative stress through urinary malondialdehyde (MDA) in leprosy and correlate them with traditional, but less sensitive markers of renal disease. METHODS: This is a cross-sectional study of 44 patients with diagnosis of leprosy and no previous tre...

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Autores principales: Meneses, Gdayllon Cavalcante, Libório, Alexandre Braga, de Daher, Elizabeth Francesco, da Silva, Geraldo Bezerra, da Costa, Marcus Felipe Bezerra, Pontes, Maria Araci Andrade, Martins, Alice Maria Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158081/
https://www.ncbi.nlm.nih.gov/pubmed/25142123
http://dx.doi.org/10.1186/1471-2334-14-451
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author Meneses, Gdayllon Cavalcante
Libório, Alexandre Braga
de Daher, Elizabeth Francesco
da Silva, Geraldo Bezerra
da Costa, Marcus Felipe Bezerra
Pontes, Maria Araci Andrade
Martins, Alice Maria Costa
author_facet Meneses, Gdayllon Cavalcante
Libório, Alexandre Braga
de Daher, Elizabeth Francesco
da Silva, Geraldo Bezerra
da Costa, Marcus Felipe Bezerra
Pontes, Maria Araci Andrade
Martins, Alice Maria Costa
author_sort Meneses, Gdayllon Cavalcante
collection PubMed
description BACKGROUND: We aimed to evaluate urinary MCP-1 and oxidative stress through urinary malondialdehyde (MDA) in leprosy and correlate them with traditional, but less sensitive markers of renal disease. METHODS: This is a cross-sectional study of 44 patients with diagnosis of leprosy and no previous treatment. Skin smear was assessed through a bacteriological index - from 0 to 6+. Glomerular filtration rate (GFR), protein excretion rate, microalbuminuria, urinary oxidative stress, malondialdehyde (MDA) and urinary MCP-1 were measured. Also, high- sensitivity C-reactive protein (hs-CRP) was measured in the blood. Fifteen healthy subjects composed a control group. RESULTS: Age and gender were similar between leprosy patients and control groups. No patient had a GFR < 60 mL/min/1.73 m2 or albumin excretion rate greater than 30 mg/g-Cr. Leprosy patients had higher urinary protein excretion (97.6 ± 69.2 vs. 6.5 ± 4.3 mg/g-Cr, p < 0.001), urinary MCP-1 (101.0 ± 79.8 vs. 34.5 ± 14.9 mg/g-Cr, p = 0.006) and urinary MDA levels (1.77 ± 1.31 vs. 1.27 ± 0.66 mmol/g-Cr, p = 0.0372) than healthy controls. There was a positive correlation between urinary MCP-1 and bacteriological index in skin smears (r = 0.322, p = 0.035), urinary protein excretion (r = 0.547, p < 0.001), albumin excretion rate (r = 0.414, p = 0.006) and urinary MDA (r = 0.453, p = 0.002). After adjusting for hs-CRP, urinary MCP-1 remained correlated with albumin excretion rate (r(partial) = 0.483, p = 0.007) and MDA levels (r(partial) = 0.555, p = 0.001). CONCLUSION: Leprosy patients with no clinical kidney disease have increased urinary MCP-1 mainly in lepromatous polar form. Inflammatory (MCP-1) and oxidative stress markers suggest leprosy patients are at high risk of developing kidney disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2334-14-451) contains supplementary material, which is available to authorized users.
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spelling pubmed-41580812014-09-10 Urinary monocyte chemotactic protein-1 (MCP-1) in leprosy patients: increased risk for kidney damage Meneses, Gdayllon Cavalcante Libório, Alexandre Braga de Daher, Elizabeth Francesco da Silva, Geraldo Bezerra da Costa, Marcus Felipe Bezerra Pontes, Maria Araci Andrade Martins, Alice Maria Costa BMC Infect Dis Research Article BACKGROUND: We aimed to evaluate urinary MCP-1 and oxidative stress through urinary malondialdehyde (MDA) in leprosy and correlate them with traditional, but less sensitive markers of renal disease. METHODS: This is a cross-sectional study of 44 patients with diagnosis of leprosy and no previous treatment. Skin smear was assessed through a bacteriological index - from 0 to 6+. Glomerular filtration rate (GFR), protein excretion rate, microalbuminuria, urinary oxidative stress, malondialdehyde (MDA) and urinary MCP-1 were measured. Also, high- sensitivity C-reactive protein (hs-CRP) was measured in the blood. Fifteen healthy subjects composed a control group. RESULTS: Age and gender were similar between leprosy patients and control groups. No patient had a GFR < 60 mL/min/1.73 m2 or albumin excretion rate greater than 30 mg/g-Cr. Leprosy patients had higher urinary protein excretion (97.6 ± 69.2 vs. 6.5 ± 4.3 mg/g-Cr, p < 0.001), urinary MCP-1 (101.0 ± 79.8 vs. 34.5 ± 14.9 mg/g-Cr, p = 0.006) and urinary MDA levels (1.77 ± 1.31 vs. 1.27 ± 0.66 mmol/g-Cr, p = 0.0372) than healthy controls. There was a positive correlation between urinary MCP-1 and bacteriological index in skin smears (r = 0.322, p = 0.035), urinary protein excretion (r = 0.547, p < 0.001), albumin excretion rate (r = 0.414, p = 0.006) and urinary MDA (r = 0.453, p = 0.002). After adjusting for hs-CRP, urinary MCP-1 remained correlated with albumin excretion rate (r(partial) = 0.483, p = 0.007) and MDA levels (r(partial) = 0.555, p = 0.001). CONCLUSION: Leprosy patients with no clinical kidney disease have increased urinary MCP-1 mainly in lepromatous polar form. Inflammatory (MCP-1) and oxidative stress markers suggest leprosy patients are at high risk of developing kidney disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2334-14-451) contains supplementary material, which is available to authorized users. BioMed Central 2014-08-20 /pmc/articles/PMC4158081/ /pubmed/25142123 http://dx.doi.org/10.1186/1471-2334-14-451 Text en © Meneses et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Meneses, Gdayllon Cavalcante
Libório, Alexandre Braga
de Daher, Elizabeth Francesco
da Silva, Geraldo Bezerra
da Costa, Marcus Felipe Bezerra
Pontes, Maria Araci Andrade
Martins, Alice Maria Costa
Urinary monocyte chemotactic protein-1 (MCP-1) in leprosy patients: increased risk for kidney damage
title Urinary monocyte chemotactic protein-1 (MCP-1) in leprosy patients: increased risk for kidney damage
title_full Urinary monocyte chemotactic protein-1 (MCP-1) in leprosy patients: increased risk for kidney damage
title_fullStr Urinary monocyte chemotactic protein-1 (MCP-1) in leprosy patients: increased risk for kidney damage
title_full_unstemmed Urinary monocyte chemotactic protein-1 (MCP-1) in leprosy patients: increased risk for kidney damage
title_short Urinary monocyte chemotactic protein-1 (MCP-1) in leprosy patients: increased risk for kidney damage
title_sort urinary monocyte chemotactic protein-1 (mcp-1) in leprosy patients: increased risk for kidney damage
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158081/
https://www.ncbi.nlm.nih.gov/pubmed/25142123
http://dx.doi.org/10.1186/1471-2334-14-451
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