Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas

BACKGROUND: Molecular mechanisms associated with frequent relapse of diffuse large B-cell lymphoma (DLBCL) are poorly defined. It is especially unclear how primary tumor clonal heterogeneity contributes to relapse. Here, we explore unique features of B-cell lymphomas - VDJ recombination and somatic...

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Detalles Bibliográficos
Autores principales: Jiang, Yanwen, Redmond, David, Nie, Kui, Eng, Ken W, Clozel, Thomas, Martin, Peter, Tan, Leonard HC, Melnick, Ari M, Tam, Wayne, Elemento, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158101/
https://www.ncbi.nlm.nih.gov/pubmed/25123191
http://dx.doi.org/10.1186/s13059-014-0432-0

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