Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain

NOD2 activation by muramyl dipeptide causes a proinflammatory immune response in which the adaptor protein CARD9 works synergistically with NOD2 to drive p38 and c-Jun N-terminal kinase (JNK) signalling. To date the nature of the interaction between NOD2 and CARD9 remains undetermined. Here we show...

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Autores principales: Parkhouse, Rhiannon, Boyle, Joseph P., Mayle, Sophie, Sawmynaden, Kovilen, Rittinger, Katrin, Monie, Tom P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158416/
https://www.ncbi.nlm.nih.gov/pubmed/24960071
http://dx.doi.org/10.1016/j.febslet.2014.06.035
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author Parkhouse, Rhiannon
Boyle, Joseph P.
Mayle, Sophie
Sawmynaden, Kovilen
Rittinger, Katrin
Monie, Tom P.
author_facet Parkhouse, Rhiannon
Boyle, Joseph P.
Mayle, Sophie
Sawmynaden, Kovilen
Rittinger, Katrin
Monie, Tom P.
author_sort Parkhouse, Rhiannon
collection PubMed
description NOD2 activation by muramyl dipeptide causes a proinflammatory immune response in which the adaptor protein CARD9 works synergistically with NOD2 to drive p38 and c-Jun N-terminal kinase (JNK) signalling. To date the nature of the interaction between NOD2 and CARD9 remains undetermined. Here we show that this interaction is not mediated by the CARDs of NOD2 and CARD9 as previously suggested, but that NOD2 possesses two interaction sites for CARD9; one in the CARD–NACHT linker and one in the NACHT itself.
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spelling pubmed-41584162014-09-10 Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain Parkhouse, Rhiannon Boyle, Joseph P. Mayle, Sophie Sawmynaden, Kovilen Rittinger, Katrin Monie, Tom P. FEBS Lett Article NOD2 activation by muramyl dipeptide causes a proinflammatory immune response in which the adaptor protein CARD9 works synergistically with NOD2 to drive p38 and c-Jun N-terminal kinase (JNK) signalling. To date the nature of the interaction between NOD2 and CARD9 remains undetermined. Here we show that this interaction is not mediated by the CARDs of NOD2 and CARD9 as previously suggested, but that NOD2 possesses two interaction sites for CARD9; one in the CARD–NACHT linker and one in the NACHT itself. John Wiley & Sons Ltd 2014-08-25 /pmc/articles/PMC4158416/ /pubmed/24960071 http://dx.doi.org/10.1016/j.febslet.2014.06.035 Text en © 2014 The Authors https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/) .
spellingShingle Article
Parkhouse, Rhiannon
Boyle, Joseph P.
Mayle, Sophie
Sawmynaden, Kovilen
Rittinger, Katrin
Monie, Tom P.
Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain
title Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain
title_full Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain
title_fullStr Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain
title_full_unstemmed Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain
title_short Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain
title_sort interaction between nod2 and card9 involves the nod2 nacht and the linker region between the nod2 cards and nacht domain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158416/
https://www.ncbi.nlm.nih.gov/pubmed/24960071
http://dx.doi.org/10.1016/j.febslet.2014.06.035
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