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Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis
Tumour necrosis factor-α (TNF-α) is a pro-inflammatory cytokine, expressed in many brain pathologies and associated with neuronal loss. We show here that addition of TNF-α to neuronal–glial co-cultures increases microglial proliferation and phagocytosis, and results in neuronal loss that is prevente...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158418/ https://www.ncbi.nlm.nih.gov/pubmed/24911209 http://dx.doi.org/10.1016/j.febslet.2014.05.046 |