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Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors

A limited therapeutic arsenal against increasing clinical disease due to Aspergillus spp. necessitates urgent characterisation of new antifungal targets. Here we describe the discovery of novel, low micromolar chemical inhibitors of Aspergillus fumigatus family 18 plant-type chitinase A1 (AfChiA1) b...

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Detalles Bibliográficos
Autores principales:	Lockhart, Deborah E.A., Schuettelkopf, Alexander, Blair, David E., van Aalten, Daan M.F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons Ltd 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158421/ https://www.ncbi.nlm.nih.gov/pubmed/25063338 http://dx.doi.org/10.1016/j.febslet.2014.07.015

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