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Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta
Osteogenesis imperfecta (OI) is a rare hereditary condition caused by changes in collagen metabolism. It is classified into four types according to clinical, genetic, and radiological criteria. Clinically, bone fragility, short stature, blue sclerae, and locomotion difficulties may be observed in th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158459/ https://www.ncbi.nlm.nih.gov/pubmed/25215248 http://dx.doi.org/10.1155/2014/384292 |
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author | Costa, Fábio Wildson Gurgel Chaves, Filipe Nobre Nogueira, Alexandre Simões Rodrigues Carvalho, Francisco Samuel Pereira, Karuza Maria Alves Kurita, Lúcio Mitsuo Rodrigues, Rodrigo Rodrigues Fonteles, Cristiane Sá Roriz |
author_facet | Costa, Fábio Wildson Gurgel Chaves, Filipe Nobre Nogueira, Alexandre Simões Rodrigues Carvalho, Francisco Samuel Pereira, Karuza Maria Alves Kurita, Lúcio Mitsuo Rodrigues, Rodrigo Rodrigues Fonteles, Cristiane Sá Roriz |
author_sort | Costa, Fábio Wildson Gurgel |
collection | PubMed |
description | Osteogenesis imperfecta (OI) is a rare hereditary condition caused by changes in collagen metabolism. It is classified into four types according to clinical, genetic, and radiological criteria. Clinically, bone fragility, short stature, blue sclerae, and locomotion difficulties may be observed in this disease. OI is often associated to severe dental problems, such as dentinogenesis imperfecta (DI) and malocclusions. Radiographically, affected teeth may have crowns with bulbous appearance, accentuated constriction in the cementoenamel junction, narrowed roots, large root canals due to defective dentin formation, and taurodontism (enlarged pulp chambers). There is no definitive cure, but bisphosphonate therapy is reported to improve bone quality; however, there is a potential risk of bisphosphonate-related osteonecrosis of the jaw. In this study we report a case of OI in a male pediatric patient with no family history of OI who was receiving ongoing treatment with intravenous perfusion of bisphosphonate and who required dental surgery. In addition, we discussed the clinical and imaging findings and briefly reviewed the literature. |
format | Online Article Text |
id | pubmed-4158459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41584592014-09-11 Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta Costa, Fábio Wildson Gurgel Chaves, Filipe Nobre Nogueira, Alexandre Simões Rodrigues Carvalho, Francisco Samuel Pereira, Karuza Maria Alves Kurita, Lúcio Mitsuo Rodrigues, Rodrigo Rodrigues Fonteles, Cristiane Sá Roriz Case Rep Dent Case Report Osteogenesis imperfecta (OI) is a rare hereditary condition caused by changes in collagen metabolism. It is classified into four types according to clinical, genetic, and radiological criteria. Clinically, bone fragility, short stature, blue sclerae, and locomotion difficulties may be observed in this disease. OI is often associated to severe dental problems, such as dentinogenesis imperfecta (DI) and malocclusions. Radiographically, affected teeth may have crowns with bulbous appearance, accentuated constriction in the cementoenamel junction, narrowed roots, large root canals due to defective dentin formation, and taurodontism (enlarged pulp chambers). There is no definitive cure, but bisphosphonate therapy is reported to improve bone quality; however, there is a potential risk of bisphosphonate-related osteonecrosis of the jaw. In this study we report a case of OI in a male pediatric patient with no family history of OI who was receiving ongoing treatment with intravenous perfusion of bisphosphonate and who required dental surgery. In addition, we discussed the clinical and imaging findings and briefly reviewed the literature. Hindawi Publishing Corporation 2014 2014-08-26 /pmc/articles/PMC4158459/ /pubmed/25215248 http://dx.doi.org/10.1155/2014/384292 Text en Copyright © 2014 Fábio Wildson Gurgel Costa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Costa, Fábio Wildson Gurgel Chaves, Filipe Nobre Nogueira, Alexandre Simões Rodrigues Carvalho, Francisco Samuel Pereira, Karuza Maria Alves Kurita, Lúcio Mitsuo Rodrigues, Rodrigo Rodrigues Fonteles, Cristiane Sá Roriz Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta |
title | Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta |
title_full | Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta |
title_fullStr | Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta |
title_full_unstemmed | Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta |
title_short | Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta |
title_sort | clinical aspects, imaging features, and considerations on bisphosphonate-related osteonecrosis risk in a pediatric patient with osteogenesis imperfecta |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158459/ https://www.ncbi.nlm.nih.gov/pubmed/25215248 http://dx.doi.org/10.1155/2014/384292 |
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