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Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta

Osteogenesis imperfecta (OI) is a rare hereditary condition caused by changes in collagen metabolism. It is classified into four types according to clinical, genetic, and radiological criteria. Clinically, bone fragility, short stature, blue sclerae, and locomotion difficulties may be observed in th...

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Autores principales: Costa, Fábio Wildson Gurgel, Chaves, Filipe Nobre, Nogueira, Alexandre Simões, Rodrigues Carvalho, Francisco Samuel, Pereira, Karuza Maria Alves, Kurita, Lúcio Mitsuo, Rodrigues, Rodrigo Rodrigues, Fonteles, Cristiane Sá Roriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158459/
https://www.ncbi.nlm.nih.gov/pubmed/25215248
http://dx.doi.org/10.1155/2014/384292
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author Costa, Fábio Wildson Gurgel
Chaves, Filipe Nobre
Nogueira, Alexandre Simões
Rodrigues Carvalho, Francisco Samuel
Pereira, Karuza Maria Alves
Kurita, Lúcio Mitsuo
Rodrigues, Rodrigo Rodrigues
Fonteles, Cristiane Sá Roriz
author_facet Costa, Fábio Wildson Gurgel
Chaves, Filipe Nobre
Nogueira, Alexandre Simões
Rodrigues Carvalho, Francisco Samuel
Pereira, Karuza Maria Alves
Kurita, Lúcio Mitsuo
Rodrigues, Rodrigo Rodrigues
Fonteles, Cristiane Sá Roriz
author_sort Costa, Fábio Wildson Gurgel
collection PubMed
description Osteogenesis imperfecta (OI) is a rare hereditary condition caused by changes in collagen metabolism. It is classified into four types according to clinical, genetic, and radiological criteria. Clinically, bone fragility, short stature, blue sclerae, and locomotion difficulties may be observed in this disease. OI is often associated to severe dental problems, such as dentinogenesis imperfecta (DI) and malocclusions. Radiographically, affected teeth may have crowns with bulbous appearance, accentuated constriction in the cementoenamel junction, narrowed roots, large root canals due to defective dentin formation, and taurodontism (enlarged pulp chambers). There is no definitive cure, but bisphosphonate therapy is reported to improve bone quality; however, there is a potential risk of bisphosphonate-related osteonecrosis of the jaw. In this study we report a case of OI in a male pediatric patient with no family history of OI who was receiving ongoing treatment with intravenous perfusion of bisphosphonate and who required dental surgery. In addition, we discussed the clinical and imaging findings and briefly reviewed the literature.
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spelling pubmed-41584592014-09-11 Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta Costa, Fábio Wildson Gurgel Chaves, Filipe Nobre Nogueira, Alexandre Simões Rodrigues Carvalho, Francisco Samuel Pereira, Karuza Maria Alves Kurita, Lúcio Mitsuo Rodrigues, Rodrigo Rodrigues Fonteles, Cristiane Sá Roriz Case Rep Dent Case Report Osteogenesis imperfecta (OI) is a rare hereditary condition caused by changes in collagen metabolism. It is classified into four types according to clinical, genetic, and radiological criteria. Clinically, bone fragility, short stature, blue sclerae, and locomotion difficulties may be observed in this disease. OI is often associated to severe dental problems, such as dentinogenesis imperfecta (DI) and malocclusions. Radiographically, affected teeth may have crowns with bulbous appearance, accentuated constriction in the cementoenamel junction, narrowed roots, large root canals due to defective dentin formation, and taurodontism (enlarged pulp chambers). There is no definitive cure, but bisphosphonate therapy is reported to improve bone quality; however, there is a potential risk of bisphosphonate-related osteonecrosis of the jaw. In this study we report a case of OI in a male pediatric patient with no family history of OI who was receiving ongoing treatment with intravenous perfusion of bisphosphonate and who required dental surgery. In addition, we discussed the clinical and imaging findings and briefly reviewed the literature. Hindawi Publishing Corporation 2014 2014-08-26 /pmc/articles/PMC4158459/ /pubmed/25215248 http://dx.doi.org/10.1155/2014/384292 Text en Copyright © 2014 Fábio Wildson Gurgel Costa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Costa, Fábio Wildson Gurgel
Chaves, Filipe Nobre
Nogueira, Alexandre Simões
Rodrigues Carvalho, Francisco Samuel
Pereira, Karuza Maria Alves
Kurita, Lúcio Mitsuo
Rodrigues, Rodrigo Rodrigues
Fonteles, Cristiane Sá Roriz
Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta
title Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta
title_full Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta
title_fullStr Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta
title_full_unstemmed Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta
title_short Clinical Aspects, Imaging Features, and Considerations on Bisphosphonate-Related Osteonecrosis Risk in a Pediatric Patient with Osteogenesis Imperfecta
title_sort clinical aspects, imaging features, and considerations on bisphosphonate-related osteonecrosis risk in a pediatric patient with osteogenesis imperfecta
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158459/
https://www.ncbi.nlm.nih.gov/pubmed/25215248
http://dx.doi.org/10.1155/2014/384292
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