Cargando…
Crystal structure of 9-(3-bromo-5-chloro-2-hydroxyphenyl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione
The title compound C(25)H(29)BrClNO(4), comprises a 3,3,6,6-tetramethyltetrahydroacridine-1,8-dione ring system that carries a hydroxyethyl substituent on the acridine N atom and a 3-bromo-5-chloro-2-hydroxyphenyl ring on the central methine C atom of the dihydropyridine ring. The benzene...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158539/ https://www.ncbi.nlm.nih.gov/pubmed/25249850 http://dx.doi.org/10.1107/S1600536814009556 |
_version_ | 1782334070417522688 |
---|---|
author | Abdelhamid, Antar A. Mohamed, Shaaban K. Simpson, Jim |
author_facet | Abdelhamid, Antar A. Mohamed, Shaaban K. Simpson, Jim |
author_sort | Abdelhamid, Antar A. |
collection | PubMed |
description | The title compound C(25)H(29)BrClNO(4), comprises a 3,3,6,6-tetramethyltetrahydroacridine-1,8-dione ring system that carries a hydroxyethyl substituent on the acridine N atom and a 3-bromo-5-chloro-2-hydroxyphenyl ring on the central methine C atom of the dihydropyridine ring. The benzene ring is inclined to the acridine ring system at an angle of 89.84 (6)° and this conformation is stabilized by an intramolecular O—H⋯O hydrogen bond between the hydroxy substituent on the benzene ring and one of the carbonyl groups of the acridinedione unit. In the crystal, O—H⋯O, C—H⋯O and C—H⋯Br hydrogen bonds combine to stack molecules in interconnected columns propagating along the a-axis direction. |
format | Online Article Text |
id | pubmed-4158539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-41585392014-09-23 Crystal structure of 9-(3-bromo-5-chloro-2-hydroxyphenyl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione Abdelhamid, Antar A. Mohamed, Shaaban K. Simpson, Jim Acta Crystallogr Sect E Struct Rep Online Research Communications The title compound C(25)H(29)BrClNO(4), comprises a 3,3,6,6-tetramethyltetrahydroacridine-1,8-dione ring system that carries a hydroxyethyl substituent on the acridine N atom and a 3-bromo-5-chloro-2-hydroxyphenyl ring on the central methine C atom of the dihydropyridine ring. The benzene ring is inclined to the acridine ring system at an angle of 89.84 (6)° and this conformation is stabilized by an intramolecular O—H⋯O hydrogen bond between the hydroxy substituent on the benzene ring and one of the carbonyl groups of the acridinedione unit. In the crystal, O—H⋯O, C—H⋯O and C—H⋯Br hydrogen bonds combine to stack molecules in interconnected columns propagating along the a-axis direction. International Union of Crystallography 2014-07-19 /pmc/articles/PMC4158539/ /pubmed/25249850 http://dx.doi.org/10.1107/S1600536814009556 Text en © Abdelhamid et al. 2014 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Research Communications Abdelhamid, Antar A. Mohamed, Shaaban K. Simpson, Jim Crystal structure of 9-(3-bromo-5-chloro-2-hydroxyphenyl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione |
title | Crystal structure of 9-(3-bromo-5-chloro-2-hydroxyphenyl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione |
title_full | Crystal structure of 9-(3-bromo-5-chloro-2-hydroxyphenyl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione |
title_fullStr | Crystal structure of 9-(3-bromo-5-chloro-2-hydroxyphenyl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione |
title_full_unstemmed | Crystal structure of 9-(3-bromo-5-chloro-2-hydroxyphenyl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione |
title_short | Crystal structure of 9-(3-bromo-5-chloro-2-hydroxyphenyl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione |
title_sort | crystal structure of 9-(3-bromo-5-chloro-2-hydroxyphenyl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2h,5h)-dione |
topic | Research Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158539/ https://www.ncbi.nlm.nih.gov/pubmed/25249850 http://dx.doi.org/10.1107/S1600536814009556 |
work_keys_str_mv | AT abdelhamidantara crystalstructureof93bromo5chloro2hydroxyphenyl102hydroxyethyl3366tetramethyl3467910hexahydroacridine182h5hdione AT mohamedshaabank crystalstructureof93bromo5chloro2hydroxyphenyl102hydroxyethyl3366tetramethyl3467910hexahydroacridine182h5hdione AT simpsonjim crystalstructureof93bromo5chloro2hydroxyphenyl102hydroxyethyl3366tetramethyl3467910hexahydroacridine182h5hdione |