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The mechanism of degeneration of striatal neuronal subtypes in Huntington disease

The pattern of neurodegeneration in Huntington’s disease (HD) is very characteristic of regional locations as well as that of neuronal types in striatum. The different striatal neuronal populations demonstrate different degree of degeneration in response to various pathological events in HD. In the...

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Autores principales: Rikani, Azadeh A., Choudhry, Zia, Choudhry, Adnan M, Rizvi, Nasir, Ikram, Huma, Mobassarah, Nusrat J, Tuli, Sagun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Indian Academy of Neurosciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158784/
https://www.ncbi.nlm.nih.gov/pubmed/25206077
http://dx.doi.org/10.5214/ans.0972.7531.210308
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author Rikani, Azadeh A.
Choudhry, Zia
Choudhry, Adnan M
Rizvi, Nasir
Ikram, Huma
Mobassarah, Nusrat J
Tuli, Sagun
author_facet Rikani, Azadeh A.
Choudhry, Zia
Choudhry, Adnan M
Rizvi, Nasir
Ikram, Huma
Mobassarah, Nusrat J
Tuli, Sagun
author_sort Rikani, Azadeh A.
collection PubMed
description The pattern of neurodegeneration in Huntington’s disease (HD) is very characteristic of regional locations as well as that of neuronal types in striatum. The different striatal neuronal populations demonstrate different degree of degeneration in response to various pathological events in HD. In the striatum, medium spiny GABA neurons (MSN) are preferentially degenerate while others are relatively spared. Vulnerability of specific neuronal populations within the striatum to pathological events constitutes an important hallmark of degeneration in HD. In an attempt to explain a likely mechanism of degeneration of striatal neuronal populations in HD, possible causes underlying differential vulnerability of neuronal subtypes to excitoxic insults and neurotrophic factors are discussed in this paper.
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spelling pubmed-41587842014-09-09 The mechanism of degeneration of striatal neuronal subtypes in Huntington disease Rikani, Azadeh A. Choudhry, Zia Choudhry, Adnan M Rizvi, Nasir Ikram, Huma Mobassarah, Nusrat J Tuli, Sagun Ann Neurosci Mini Review The pattern of neurodegeneration in Huntington’s disease (HD) is very characteristic of regional locations as well as that of neuronal types in striatum. The different striatal neuronal populations demonstrate different degree of degeneration in response to various pathological events in HD. In the striatum, medium spiny GABA neurons (MSN) are preferentially degenerate while others are relatively spared. Vulnerability of specific neuronal populations within the striatum to pathological events constitutes an important hallmark of degeneration in HD. In an attempt to explain a likely mechanism of degeneration of striatal neuronal populations in HD, possible causes underlying differential vulnerability of neuronal subtypes to excitoxic insults and neurotrophic factors are discussed in this paper. Indian Academy of Neurosciences 2014-07 /pmc/articles/PMC4158784/ /pubmed/25206077 http://dx.doi.org/10.5214/ans.0972.7531.210308 Text en Copyright © 2014, The National Academy of Sciences http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini Review
Rikani, Azadeh A.
Choudhry, Zia
Choudhry, Adnan M
Rizvi, Nasir
Ikram, Huma
Mobassarah, Nusrat J
Tuli, Sagun
The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
title The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
title_full The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
title_fullStr The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
title_full_unstemmed The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
title_short The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
title_sort mechanism of degeneration of striatal neuronal subtypes in huntington disease
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158784/
https://www.ncbi.nlm.nih.gov/pubmed/25206077
http://dx.doi.org/10.5214/ans.0972.7531.210308
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