Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation

The conserved eukaryotic Pan2–Pan3 deadenylation complex shortens cytoplasmic mRNA 3′ polyA tails to regulate mRNA stability. Although the exonuclease activity resides in Pan2, efficient deadenylation requires Pan3. The mechanistic role of Pan3 is unclear. Here, we show that Pan3 binds RNA directly...

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Detalles Bibliográficos
Autores principales: Wolf, Jana, Valkov, Eugene, Allen, Mark D, Meineke, Birthe, Gordiyenko, Yuliya, McLaughlin, Stephen H, Olsen, Tayla M, Robinson, Carol V, Bycroft, Mark, Stewart, Murray, Passmore, Lori A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158885/
https://www.ncbi.nlm.nih.gov/pubmed/24872509
http://dx.doi.org/10.15252/embj.201488373

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