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Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers
Many marine triterpene glycosides have in vitro and in vivo activities with very low toxicity, suggesting that they are suitable agents for the prevention and treatment of different diseases, particularly cancer. However, the molecular mechanisms of action of natural marine compounds in cancer, immu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159031/ https://www.ncbi.nlm.nih.gov/pubmed/25250309 http://dx.doi.org/10.3389/fchem.2014.00077 |
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author | Park, Joo-In Bae, Hae-Rahn Kim, Chang Gun Stonik, Valentin A. Kwak, Jong-Young |
author_facet | Park, Joo-In Bae, Hae-Rahn Kim, Chang Gun Stonik, Valentin A. Kwak, Jong-Young |
author_sort | Park, Joo-In |
collection | PubMed |
description | Many marine triterpene glycosides have in vitro and in vivo activities with very low toxicity, suggesting that they are suitable agents for the prevention and treatment of different diseases, particularly cancer. However, the molecular mechanisms of action of natural marine compounds in cancer, immune, and other various cells are not fully known. This review focuses on the structural characteristics of marine triterpene glycosides and how these affect their biological activities and molecular mechanisms. In particular, the membranotropic and membranolytic activities of frondoside A and cucumariosides from sea cucumbers and their ability to induce cytotoxicity and apoptosis have been discussed, with a focus on structure-activity relationships. In addition, the structural characteristics and antitumor effects of stichoposide C and stichoposide D have been reviewed along with underlying their molecular mechanisms. |
format | Online Article Text |
id | pubmed-4159031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41590312014-09-23 Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers Park, Joo-In Bae, Hae-Rahn Kim, Chang Gun Stonik, Valentin A. Kwak, Jong-Young Front Chem Chemistry Many marine triterpene glycosides have in vitro and in vivo activities with very low toxicity, suggesting that they are suitable agents for the prevention and treatment of different diseases, particularly cancer. However, the molecular mechanisms of action of natural marine compounds in cancer, immune, and other various cells are not fully known. This review focuses on the structural characteristics of marine triterpene glycosides and how these affect their biological activities and molecular mechanisms. In particular, the membranotropic and membranolytic activities of frondoside A and cucumariosides from sea cucumbers and their ability to induce cytotoxicity and apoptosis have been discussed, with a focus on structure-activity relationships. In addition, the structural characteristics and antitumor effects of stichoposide C and stichoposide D have been reviewed along with underlying their molecular mechanisms. Frontiers Media S.A. 2014-09-09 /pmc/articles/PMC4159031/ /pubmed/25250309 http://dx.doi.org/10.3389/fchem.2014.00077 Text en Copyright © 2014 Park, Bae, Kim, Stonik and Kwak. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Park, Joo-In Bae, Hae-Rahn Kim, Chang Gun Stonik, Valentin A. Kwak, Jong-Young Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
title | Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
title_full | Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
title_fullStr | Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
title_full_unstemmed | Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
title_short | Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
title_sort | relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159031/ https://www.ncbi.nlm.nih.gov/pubmed/25250309 http://dx.doi.org/10.3389/fchem.2014.00077 |
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