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De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive oxygen species (ROS)–scavenging enzymes and drug efflux pumps, but how these genes are up-regulated in response to de-...

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Detalles Bibliográficos
Autores principales:	Del Vecchio, Catherine A., Feng, Yuxiong, Sokol, Ethan S., Tillman, Erik J., Sanduja, Sandhya, Reinhardt, Ferenc, Gupta, Piyush B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159113/ https://www.ncbi.nlm.nih.gov/pubmed/25203443 http://dx.doi.org/10.1371/journal.pbio.1001945

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