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Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms

Fused in sarcoma (FUS) is an RNA-binding protein involved in pathogenesis of several neurodegenerative diseases. Aggregation of mislocalized FUS into non-amyloid inclusions is believed to be pivotal in the development of cell dysfunction, but the mechanism of their formation is unclear. Using transi...

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Detalles Bibliográficos
Autores principales:	Shelkovnikova, Tatyana A., Robinson, Hannah K., Southcombe, Joshua A., Ninkina, Natalia, Buchman, Vladimir L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159159/ https://www.ncbi.nlm.nih.gov/pubmed/24842888 http://dx.doi.org/10.1093/hmg/ddu243

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