Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity

Compared with normal differentiated cells, cancer cells upregulate the expression of pyruvate kinase isozyme M2 (PKM2) to support glycolytic intermediates for anabolic processes, including the synthesis of nucleic acids, amino acids, and lipids. In this study, a combination of the structure-based ph...

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Detalles Bibliográficos
Autores principales: Chen, Can, Wang, Ting, Wu, Fengbo, Huang, Wei, He, Gu, Ouyang, Liang, Xiang, Mingli, Peng, Cheng, Jiang, Qinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159224/
https://www.ncbi.nlm.nih.gov/pubmed/25214764
http://dx.doi.org/10.2147/DDDT.S62921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159224/
https://www.ncbi.nlm.nih.gov/pubmed/25214764
http://dx.doi.org/10.2147/DDDT.S62921

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