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An individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma

OBJECTIVE: To investigate the pathology and pathogenesis of and treatment methods for temporal bone verrucous carcinoma. MATERIALS AND METHODS: A single-patient report of verrucous carcinoma on the left external auditory canal is presented and analyzed along with all cases of temporal bone verrucous...

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Autores principales: Tan, Haolei, Liu, Yong, Zhu, Gangcai, Pi, Leiming, Huang, Donghai, Zhang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159496/
https://www.ncbi.nlm.nih.gov/pubmed/25214794
http://dx.doi.org/10.2147/OTT.S66145
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author Tan, Haolei
Liu, Yong
Zhu, Gangcai
Pi, Leiming
Huang, Donghai
Zhang, Xin
author_facet Tan, Haolei
Liu, Yong
Zhu, Gangcai
Pi, Leiming
Huang, Donghai
Zhang, Xin
author_sort Tan, Haolei
collection PubMed
description OBJECTIVE: To investigate the pathology and pathogenesis of and treatment methods for temporal bone verrucous carcinoma. MATERIALS AND METHODS: A single-patient report of verrucous carcinoma on the left external auditory canal is presented and analyzed along with all cases of temporal bone verrucous carcinoma that have been documented in the English literature. RESULTS: Most of the patients with verrucous carcinoma of the temporal bone have histories of surgery, trauma, or infection, and verrucous carcinomas are sensitive to antimicrotubule chemotherapeutic medicines. Adjuvant radiation therapy is not effective, but surgical treatment might be relatively more effective. CONCLUSION: Temporal bone verrucous carcinoma has a poor prognosis; therefore, the preferred treatment is surgical resection facilitated with antimicrotubule chemotherapeutic treatment. Adjuvant radiation therapy is not a preferred treatment for temporal bone verrucous carcinoma.
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spelling pubmed-41594962014-09-11 An individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma Tan, Haolei Liu, Yong Zhu, Gangcai Pi, Leiming Huang, Donghai Zhang, Xin Onco Targets Ther Original Research OBJECTIVE: To investigate the pathology and pathogenesis of and treatment methods for temporal bone verrucous carcinoma. MATERIALS AND METHODS: A single-patient report of verrucous carcinoma on the left external auditory canal is presented and analyzed along with all cases of temporal bone verrucous carcinoma that have been documented in the English literature. RESULTS: Most of the patients with verrucous carcinoma of the temporal bone have histories of surgery, trauma, or infection, and verrucous carcinomas are sensitive to antimicrotubule chemotherapeutic medicines. Adjuvant radiation therapy is not effective, but surgical treatment might be relatively more effective. CONCLUSION: Temporal bone verrucous carcinoma has a poor prognosis; therefore, the preferred treatment is surgical resection facilitated with antimicrotubule chemotherapeutic treatment. Adjuvant radiation therapy is not a preferred treatment for temporal bone verrucous carcinoma. Dove Medical Press 2014-09-04 /pmc/articles/PMC4159496/ /pubmed/25214794 http://dx.doi.org/10.2147/OTT.S66145 Text en © 2014 Tan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Tan, Haolei
Liu, Yong
Zhu, Gangcai
Pi, Leiming
Huang, Donghai
Zhang, Xin
An individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma
title An individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma
title_full An individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma
title_fullStr An individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma
title_full_unstemmed An individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma
title_short An individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma
title_sort individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159496/
https://www.ncbi.nlm.nih.gov/pubmed/25214794
http://dx.doi.org/10.2147/OTT.S66145
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