CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity

Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising in young children. In this study, we sought to evaluate the diagnostic specificity of C19MC and LIN28, and the clinical and...

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Detalles Bibliográficos
Autores principales: Spence, Tara, Sin-Chan, Patrick, Picard, Daniel, Barszczyk, Mark, Hoss, Katharina, Lu, Mei, Kim, Seung-Ki, Ra, Young-Shin, Nakamura, Hideo, Fangusaro, Jason, Hwang, Eugene, Kiehna, Erin, Toledano, Helen, Wang, Yin, Shi, Qing, Johnston, Donna, Michaud, Jean, La Spina, Milena, Buccoliero, Anna Maria, Adamek, Dariusz, Camelo-Piragua, Sandra, Peter Collins, V., Jones, Chris, Kabbara, Nabil, Jurdi, Nawaf, Varlet, Pascale, Perry, Arie, Scharnhorst, David, Fan, Xing, Muraszko, Karin M., Eberhart, Charles G., Ng, Ho-Keung, Gururangan, Sridharan, Van Meter, Timothy, Remke, Marc, Lafay-Cousin, Lucie, Chan, Jennifer A., Sirachainan, Nongnuch, Pomeroy, Scott L., Clifford, Steven C., Gajjar, Amar, Shago, Mary, Halliday, William, Taylor, Michael D., Grundy, Richard, Lau, Ching C., Phillips, Joanna, Bouffet, Eric, Dirks, Peter B., Hawkins, Cynthia E., Huang, Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159569/
https://www.ncbi.nlm.nih.gov/pubmed/24839957
http://dx.doi.org/10.1007/s00401-014-1291-1

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