C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration

Hexanucleotide repeat expansion in C9orf72 is the most common pathogenic mutation in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Despite the lack of an ATG start codon, the repeat expansion is translated in all reading frames into dipeptide repeat...

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Detalles Bibliográficos
Autores principales: May, Stephanie, Hornburg, Daniel, Schludi, Martin H., Arzberger, Thomas, Rentzsch, Kristin, Schwenk, Benjamin M., Grässer, Friedrich A., Mori, Kohji, Kremmer, Elisabeth, Banzhaf-Strathmann, Julia, Mann, Matthias, Meissner, Felix, Edbauer, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159571/
https://www.ncbi.nlm.nih.gov/pubmed/25120191
http://dx.doi.org/10.1007/s00401-014-1329-4

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