Small-Molecule Proteomimetic Inhibitors of the HIF-1α–p300 Protein–Protein Interaction

The therapeutically relevant hypoxia inducible factor HIF-1α–p300 protein–protein interaction can be orthosterically inhibited with α-helix mimetics based on an oligoamide scaffold that recapitulates essential features of the C-terminal helix of the HIF-1α C-TAD (C-terminal transactivation domain)....

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Detalles Bibliográficos
Autores principales: Burslem, George M, Kyle, Hannah F, Breeze, Alexander L, Edwards, Thomas A, Nelson, Adam, Warriner, Stuart L, Wilson, Andrew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159589/
https://www.ncbi.nlm.nih.gov/pubmed/24782431
http://dx.doi.org/10.1002/cbic.201400009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159589/
https://www.ncbi.nlm.nih.gov/pubmed/24782431
http://dx.doi.org/10.1002/cbic.201400009

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