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Small-Molecule Proteomimetic Inhibitors of the HIF-1α–p300 Protein–Protein Interaction
The therapeutically relevant hypoxia inducible factor HIF-1α–p300 protein–protein interaction can be orthosterically inhibited with α-helix mimetics based on an oligoamide scaffold that recapitulates essential features of the C-terminal helix of the HIF-1α C-TAD (C-terminal transactivation domain)....
Autores principales: | Burslem, George M, Kyle, Hannah F, Breeze, Alexander L, Edwards, Thomas A, Nelson, Adam, Warriner, Stuart L, Wilson, Andrew J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159589/ https://www.ncbi.nlm.nih.gov/pubmed/24782431 http://dx.doi.org/10.1002/cbic.201400009 |
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