The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle Development

The sine oculis homeobox 1 (Six1) gene encodes an evolutionarily conserved transcription factor. In the past two decades, much research has indicated that Six1 is a powerful regulator participating in skeletal muscle development. In this review, we summarized the discovery and structural characteris...

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Autores principales: Wu, Wangjun, Huang, Ruihua, Wu, Qinghua, Li, Pinghua, Chen, Jie, Li, Bojiang, Liu, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159689/
https://www.ncbi.nlm.nih.gov/pubmed/25210496
http://dx.doi.org/10.7150/ijbs.9442
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author Wu, Wangjun
Huang, Ruihua
Wu, Qinghua
Li, Pinghua
Chen, Jie
Li, Bojiang
Liu, Honglin
author_facet Wu, Wangjun
Huang, Ruihua
Wu, Qinghua
Li, Pinghua
Chen, Jie
Li, Bojiang
Liu, Honglin
author_sort Wu, Wangjun
collection PubMed
description The sine oculis homeobox 1 (Six1) gene encodes an evolutionarily conserved transcription factor. In the past two decades, much research has indicated that Six1 is a powerful regulator participating in skeletal muscle development. In this review, we summarized the discovery and structural characteristics of Six1 gene, and discussed the functional roles and molecular mechanisms of Six1 in myogenesis and in the formation of skeletal muscle fibers. Finally, we proposed areas of future interest for understanding Six1 gene function.
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spelling pubmed-41596892014-09-10 The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle Development Wu, Wangjun Huang, Ruihua Wu, Qinghua Li, Pinghua Chen, Jie Li, Bojiang Liu, Honglin Int J Biol Sci Review The sine oculis homeobox 1 (Six1) gene encodes an evolutionarily conserved transcription factor. In the past two decades, much research has indicated that Six1 is a powerful regulator participating in skeletal muscle development. In this review, we summarized the discovery and structural characteristics of Six1 gene, and discussed the functional roles and molecular mechanisms of Six1 in myogenesis and in the formation of skeletal muscle fibers. Finally, we proposed areas of future interest for understanding Six1 gene function. Ivyspring International Publisher 2014-09-05 /pmc/articles/PMC4159689/ /pubmed/25210496 http://dx.doi.org/10.7150/ijbs.9442 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
Wu, Wangjun
Huang, Ruihua
Wu, Qinghua
Li, Pinghua
Chen, Jie
Li, Bojiang
Liu, Honglin
The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle Development
title The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle Development
title_full The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle Development
title_fullStr The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle Development
title_full_unstemmed The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle Development
title_short The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle Development
title_sort role of six1 in the genesis of muscle cell and skeletal muscle development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159689/
https://www.ncbi.nlm.nih.gov/pubmed/25210496
http://dx.doi.org/10.7150/ijbs.9442
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