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Non-Coding RNAs and Lipid Metabolism
A high percentage of the mammalian genome consists of non-coding RNAs (ncRNAs). Among ncRNAs two main subgroups have been identified: long ncRNAs (lncRNAs) and micro RNAs (miRNAs). ncRNAs have been demonstrated to play a role in a vast variety of diseases, since they regulate gene transcription and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159807/ https://www.ncbi.nlm.nih.gov/pubmed/25093715 http://dx.doi.org/10.3390/ijms150813494 |
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author | Smolle, Elisabeth Haybaeck, Johannes |
author_facet | Smolle, Elisabeth Haybaeck, Johannes |
author_sort | Smolle, Elisabeth |
collection | PubMed |
description | A high percentage of the mammalian genome consists of non-coding RNAs (ncRNAs). Among ncRNAs two main subgroups have been identified: long ncRNAs (lncRNAs) and micro RNAs (miRNAs). ncRNAs have been demonstrated to play a role in a vast variety of diseases, since they regulate gene transcription and are involved in post-transcriptional regulation. They have the potential to function as molecular signals or as guides for transcription factors and to regulate epigenetic modifiers. In this literature review we have summarized data on miRNAs and lncRNAs and their involvement in dyslipidaemia, atherosclerosis, insulin resistance and adipogenesis. Outlining certain ncRNAs as disease biomarkers and/or therapeutic targets, and testing them in vivo, will be the next steps in future research. |
format | Online Article Text |
id | pubmed-4159807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41598072014-09-18 Non-Coding RNAs and Lipid Metabolism Smolle, Elisabeth Haybaeck, Johannes Int J Mol Sci Review A high percentage of the mammalian genome consists of non-coding RNAs (ncRNAs). Among ncRNAs two main subgroups have been identified: long ncRNAs (lncRNAs) and micro RNAs (miRNAs). ncRNAs have been demonstrated to play a role in a vast variety of diseases, since they regulate gene transcription and are involved in post-transcriptional regulation. They have the potential to function as molecular signals or as guides for transcription factors and to regulate epigenetic modifiers. In this literature review we have summarized data on miRNAs and lncRNAs and their involvement in dyslipidaemia, atherosclerosis, insulin resistance and adipogenesis. Outlining certain ncRNAs as disease biomarkers and/or therapeutic targets, and testing them in vivo, will be the next steps in future research. MDPI 2014-08-04 /pmc/articles/PMC4159807/ /pubmed/25093715 http://dx.doi.org/10.3390/ijms150813494 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Smolle, Elisabeth Haybaeck, Johannes Non-Coding RNAs and Lipid Metabolism |
title | Non-Coding RNAs and Lipid Metabolism |
title_full | Non-Coding RNAs and Lipid Metabolism |
title_fullStr | Non-Coding RNAs and Lipid Metabolism |
title_full_unstemmed | Non-Coding RNAs and Lipid Metabolism |
title_short | Non-Coding RNAs and Lipid Metabolism |
title_sort | non-coding rnas and lipid metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159807/ https://www.ncbi.nlm.nih.gov/pubmed/25093715 http://dx.doi.org/10.3390/ijms150813494 |
work_keys_str_mv | AT smolleelisabeth noncodingrnasandlipidmetabolism AT haybaeckjohannes noncodingrnasandlipidmetabolism |