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Effect of β-Glucan Supplementation on Acute Postprandial Changes in Fatty Acid Profile of Lymph and Serum in Pigs

Triglycerides are absorbed by the lymphatic system and have various functions in the body. It has been shown that some types of β-glucans have a positive effect on the systemic concentrations of cholesterol and lipid, presumably through interference with the absorption of lipid and/or reabsorption o...

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Autores principales: Lærke, Helle Nygaard, Mikkelsen, Lasse Sommer, Jørgensen, Henry, Jensen, Søren Krogh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159829/
https://www.ncbi.nlm.nih.gov/pubmed/25116686
http://dx.doi.org/10.3390/ijms150813881
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author Lærke, Helle Nygaard
Mikkelsen, Lasse Sommer
Jørgensen, Henry
Jensen, Søren Krogh
author_facet Lærke, Helle Nygaard
Mikkelsen, Lasse Sommer
Jørgensen, Henry
Jensen, Søren Krogh
author_sort Lærke, Helle Nygaard
collection PubMed
description Triglycerides are absorbed by the lymphatic system and have various functions in the body. It has been shown that some types of β-glucans have a positive effect on the systemic concentrations of cholesterol and lipid, presumably through interference with the absorption of lipid and/or reabsorption of bile acids. In the current study we investigated the acute effects of ingesting 2 g of β-glucan concentrates derived from barley β-(1→3)(1→4)-d-glucan or yeast β-(1→3)(1→6)-d-glucan on fatty acid content and composition in lymph and serum of 10 female pigs (initial weight 34.7 ± 1.1 kg) fitted with a permanent catheter in the jejunal lymphatic trunk in a cross-over design. Lymph was collected continuously for 8 h followed by a spot sample taken 24 h after. A significant effect of time after feeding was observed for all fatty acids in serum and for 18:0, 18:2ω6 and 18:3ω3 in lymph, but a significant effect of β-glucan was only observed for 14:0 (p = 0.049) and 22:6ω3 (p = 0.048) in lymph and 18:0 (p = 0.019) in serum. While the concentration of dietary fatty acids increased postprandially in lymph, the concentration of arachidonic and docahexanoic acid tended to decrease. Furthermore, there was a drop in concentration of all fatty acid in serum 1 h after the meal.
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spelling pubmed-41598292014-09-18 Effect of β-Glucan Supplementation on Acute Postprandial Changes in Fatty Acid Profile of Lymph and Serum in Pigs Lærke, Helle Nygaard Mikkelsen, Lasse Sommer Jørgensen, Henry Jensen, Søren Krogh Int J Mol Sci Article Triglycerides are absorbed by the lymphatic system and have various functions in the body. It has been shown that some types of β-glucans have a positive effect on the systemic concentrations of cholesterol and lipid, presumably through interference with the absorption of lipid and/or reabsorption of bile acids. In the current study we investigated the acute effects of ingesting 2 g of β-glucan concentrates derived from barley β-(1→3)(1→4)-d-glucan or yeast β-(1→3)(1→6)-d-glucan on fatty acid content and composition in lymph and serum of 10 female pigs (initial weight 34.7 ± 1.1 kg) fitted with a permanent catheter in the jejunal lymphatic trunk in a cross-over design. Lymph was collected continuously for 8 h followed by a spot sample taken 24 h after. A significant effect of time after feeding was observed for all fatty acids in serum and for 18:0, 18:2ω6 and 18:3ω3 in lymph, but a significant effect of β-glucan was only observed for 14:0 (p = 0.049) and 22:6ω3 (p = 0.048) in lymph and 18:0 (p = 0.019) in serum. While the concentration of dietary fatty acids increased postprandially in lymph, the concentration of arachidonic and docahexanoic acid tended to decrease. Furthermore, there was a drop in concentration of all fatty acid in serum 1 h after the meal. MDPI 2014-08-11 /pmc/articles/PMC4159829/ /pubmed/25116686 http://dx.doi.org/10.3390/ijms150813881 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lærke, Helle Nygaard
Mikkelsen, Lasse Sommer
Jørgensen, Henry
Jensen, Søren Krogh
Effect of β-Glucan Supplementation on Acute Postprandial Changes in Fatty Acid Profile of Lymph and Serum in Pigs
title Effect of β-Glucan Supplementation on Acute Postprandial Changes in Fatty Acid Profile of Lymph and Serum in Pigs
title_full Effect of β-Glucan Supplementation on Acute Postprandial Changes in Fatty Acid Profile of Lymph and Serum in Pigs
title_fullStr Effect of β-Glucan Supplementation on Acute Postprandial Changes in Fatty Acid Profile of Lymph and Serum in Pigs
title_full_unstemmed Effect of β-Glucan Supplementation on Acute Postprandial Changes in Fatty Acid Profile of Lymph and Serum in Pigs
title_short Effect of β-Glucan Supplementation on Acute Postprandial Changes in Fatty Acid Profile of Lymph and Serum in Pigs
title_sort effect of β-glucan supplementation on acute postprandial changes in fatty acid profile of lymph and serum in pigs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159829/
https://www.ncbi.nlm.nih.gov/pubmed/25116686
http://dx.doi.org/10.3390/ijms150813881
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