Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer

The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been eluci...

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Detalles Bibliográficos
Autores principales: Smolle, Maria, Uranitsch, Stefan, Gerger, Armin, Pichler, Martin, Haybaeck, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159835/
https://www.ncbi.nlm.nih.gov/pubmed/25119862
http://dx.doi.org/10.3390/ijms150813993
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author Smolle, Maria
Uranitsch, Stefan
Gerger, Armin
Pichler, Martin
Haybaeck, Johannes
author_facet Smolle, Maria
Uranitsch, Stefan
Gerger, Armin
Pichler, Martin
Haybaeck, Johannes
author_sort Smolle, Maria
collection PubMed
description The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide.
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spelling pubmed-41598352014-09-18 Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer Smolle, Maria Uranitsch, Stefan Gerger, Armin Pichler, Martin Haybaeck, Johannes Int J Mol Sci Review The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide. MDPI 2014-08-12 /pmc/articles/PMC4159835/ /pubmed/25119862 http://dx.doi.org/10.3390/ijms150813993 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Smolle, Maria
Uranitsch, Stefan
Gerger, Armin
Pichler, Martin
Haybaeck, Johannes
Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
title Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
title_full Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
title_fullStr Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
title_full_unstemmed Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
title_short Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
title_sort current status of long non-coding rnas in human cancer with specific focus on colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159835/
https://www.ncbi.nlm.nih.gov/pubmed/25119862
http://dx.doi.org/10.3390/ijms150813993
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