Matrilin-3 Chondrodysplasia Mutations Cause Attenuated Chondrogenesis, Premature Hypertrophy and Aberrant Response to TGF-β in Chondroprogenitor Cells

Studies have shown that mutations in the matrilin-3 gene (MATN3) are associated with multiple epiphyseal dysplasia (MED) and spondyloepimetaphyseal dysplasia (SEMD). We tested whether MATN3 mutations affect the differentiation of chondroprogenitor and/or mesenchymal stem cells, which are precursors...

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Detalles Bibliográficos
Autores principales: Jayasuriya, Chathuraka T., Zhou, Fiona H., Pei, Ming, Wang, Zhengke, Lemme, Nicholas J., Haines, Paul, Chen, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159868/
https://www.ncbi.nlm.nih.gov/pubmed/25196597
http://dx.doi.org/10.3390/ijms150814555

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