Structural changes of CFTR R region upon phosphorylation: a plastic platform for intramolecular and intermolecular interactions

Chloride channel gating and trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) are regulated by phosphorylation. Intrinsically disordered segments of the protein are responsible for phospho‐regulation, particularly the regulatory (R) region that is a target for several kin...

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Detalles Bibliográficos
Autores principales: Bozoky, Zoltan, Krzeminski, Mickael, Chong, P. Andrew, Forman‐Kay, Julie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160016/
https://www.ncbi.nlm.nih.gov/pubmed/23826884
http://dx.doi.org/10.1111/febs.12422

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