Dose-sparing and safety-enhancing effects of an IGF-I-based dosing regimen in short children treated with growth hormone in a 2-year randomized controlled trial: therapeutic and pharmacoeconomic considerations

CONTEXT AND OBJECTIVE: Titrating the dosage of growth hormone (GH) to serum levels of insulin-like growth factor-I (IGF-I) is a feasible treatment strategy in children with GH deficiency (GHD) and idiopathic short stature (ISS). The objective was to assess the dose-sparing effect and theoretical saf...

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Detalles Bibliográficos
Autores principales: Cohen, Pinchas, Weng, Wayne, Rogol, Alan D, Rosenfeld, Ron G, Kappelgaard, Anne-Marie, Germak, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160145/
https://www.ncbi.nlm.nih.gov/pubmed/24428305
http://dx.doi.org/10.1111/cen.12408

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