G-Quadruplex Structures Formed by Expanded Hexanucleotide Repeat RNA and DNA from the Neurodegenerative Disease-Linked C9orf72 Gene Efficiently Sequester and Activate Heme

The expansion of a (G(4)C(2))(n) repeat within the human C9orf72 gene has been causally linked to a number of neurodegenerative diseases, most notably familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recent studies have shown that the repeat expansion alters gene funct...

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Detalles Bibliográficos
Autores principales: Grigg, Jason C., Shumayrikh, Nisreen, Sen, Dipankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160187/
https://www.ncbi.nlm.nih.gov/pubmed/25207541
http://dx.doi.org/10.1371/journal.pone.0106449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160187/
https://www.ncbi.nlm.nih.gov/pubmed/25207541
http://dx.doi.org/10.1371/journal.pone.0106449

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