Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease

[Image: see text] Defective autophagy in Alzheimer’s disease (AD) promotes disease progression in diverse ways. Here, we demonstrate impaired autophagy flux in primary glial cells derived from CRND8 mice that overexpress mutant amyloid precursor protein (APP). Functionalized single-walled carbon nan...

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Autores principales: Xue, Xue, Wang, Li-Rong, Sato, Yutaka, Jiang, Ying, Berg, Martin, Yang, Dun-Sheng, Nixon, Ralph A., Liang, Xing-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160261/
https://www.ncbi.nlm.nih.gov/pubmed/25115676
http://dx.doi.org/10.1021/nl501839q
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author Xue, Xue
Wang, Li-Rong
Sato, Yutaka
Jiang, Ying
Berg, Martin
Yang, Dun-Sheng
Nixon, Ralph A.
Liang, Xing-Jie
author_facet Xue, Xue
Wang, Li-Rong
Sato, Yutaka
Jiang, Ying
Berg, Martin
Yang, Dun-Sheng
Nixon, Ralph A.
Liang, Xing-Jie
author_sort Xue, Xue
collection PubMed
description [Image: see text] Defective autophagy in Alzheimer’s disease (AD) promotes disease progression in diverse ways. Here, we demonstrate impaired autophagy flux in primary glial cells derived from CRND8 mice that overexpress mutant amyloid precursor protein (APP). Functionalized single-walled carbon nanotubes (SWNT) restored normal autophagy by reversing abnormal activation of mTOR signaling and deficits in lysosomal proteolysis, thereby facilitating elimination of autophagic substrates. These findings suggest SWNT as a novel neuroprotective approach to AD therapy.
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spelling pubmed-41602612015-08-12 Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease Xue, Xue Wang, Li-Rong Sato, Yutaka Jiang, Ying Berg, Martin Yang, Dun-Sheng Nixon, Ralph A. Liang, Xing-Jie Nano Lett [Image: see text] Defective autophagy in Alzheimer’s disease (AD) promotes disease progression in diverse ways. Here, we demonstrate impaired autophagy flux in primary glial cells derived from CRND8 mice that overexpress mutant amyloid precursor protein (APP). Functionalized single-walled carbon nanotubes (SWNT) restored normal autophagy by reversing abnormal activation of mTOR signaling and deficits in lysosomal proteolysis, thereby facilitating elimination of autophagic substrates. These findings suggest SWNT as a novel neuroprotective approach to AD therapy. American Chemical Society 2014-08-12 2014-09-10 /pmc/articles/PMC4160261/ /pubmed/25115676 http://dx.doi.org/10.1021/nl501839q Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Xue, Xue
Wang, Li-Rong
Sato, Yutaka
Jiang, Ying
Berg, Martin
Yang, Dun-Sheng
Nixon, Ralph A.
Liang, Xing-Jie
Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease
title Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease
title_full Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease
title_fullStr Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease
title_full_unstemmed Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease
title_short Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease
title_sort single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of alzheimer’s disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160261/
https://www.ncbi.nlm.nih.gov/pubmed/25115676
http://dx.doi.org/10.1021/nl501839q
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