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The Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibitor PJ34 Reduces Pulmonary Ischemia-Reperfusion Injury in Rats

BACKGROUND: Ischemia-reperfusion (I/R) injury after lung transplantation causes alveolar damage, lung edema, and acute rejection. Poly(adenosine diphosphate-ribose) polymerase (PARP) is a single-stranded DNA repair enzyme that induces apoptosis and necrosis after DNA damage caused by reactive oxygen...

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Detalles Bibliográficos
Autores principales:	Hatachi, Go, Tsuchiya, Tomoshi, Miyazaki, Takuro, Matsumoto, Keitaro, Yamasaki, Naoya, Okita, Naoyuki, Nanashima, Atsushi, Higami, Yoshikazu, Nagayasu, Takeshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2014
Materias:	Basic and Experimental Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160283/ https://www.ncbi.nlm.nih.gov/pubmed/25221900 http://dx.doi.org/10.1097/TP.0000000000000305

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