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Heat Shock Protein 60 Overexpression Is Associated with the Progression and Prognosis in Gastric Cancer
BACKGROUND: Heat shock protein 60 (HSP60) is a chaperonin with essential functions for cell physiology and survival, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of HSP60 status with clinicopathological parameters an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160299/ https://www.ncbi.nlm.nih.gov/pubmed/25207654 http://dx.doi.org/10.1371/journal.pone.0107507 |
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author | Li, Xiao-shan Xu, Qing Fu, Xiang-yang Luo, Wei-sheng |
author_facet | Li, Xiao-shan Xu, Qing Fu, Xiang-yang Luo, Wei-sheng |
author_sort | Li, Xiao-shan |
collection | PubMed |
description | BACKGROUND: Heat shock protein 60 (HSP60) is a chaperonin with essential functions for cell physiology and survival, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of HSP60 status with clinicopathological parameters and prognosis in gastric cancer. METHODS: The levels of HSP60 and matrix metallopeptidase 9 (MMP-9) antigen was evaluated by immunohistochemistry in 223 gastric carcinoma samples. The association between HSP60 and MMP-9, clinicopathological parameters, and prognosis of gastric cancer was examined. RESULTS: The level of HSP60 protein was significantly associated with depth invasion, lymph node metastasis and stage of disease (all P<0.05). Both univariate and multivariate analyses revealed that HSP60 was an independent prognostic factor for both overall survival (OS) and recurrence-free survival (RFS) (both P<0.05). Furthermore, HSP60 overexpression was associated with a poor prognosis in patients with advanced gastric cancer in different risk groups. Moreover, HSP60 was significantly correlated with MMP-9 among 223 gastric cancer tissues (P<0.001). Patients who had HSP60 overexpression, in which tumor cells displayed high invasiveness, had poor OS and shorter RFS. CONCLUSION: HSP60 plays an important role on tumor aggressiveness and prognosis, and may act as a promising target for prognostic prediction. |
format | Online Article Text |
id | pubmed-4160299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41602992014-09-12 Heat Shock Protein 60 Overexpression Is Associated with the Progression and Prognosis in Gastric Cancer Li, Xiao-shan Xu, Qing Fu, Xiang-yang Luo, Wei-sheng PLoS One Research Article BACKGROUND: Heat shock protein 60 (HSP60) is a chaperonin with essential functions for cell physiology and survival, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of HSP60 status with clinicopathological parameters and prognosis in gastric cancer. METHODS: The levels of HSP60 and matrix metallopeptidase 9 (MMP-9) antigen was evaluated by immunohistochemistry in 223 gastric carcinoma samples. The association between HSP60 and MMP-9, clinicopathological parameters, and prognosis of gastric cancer was examined. RESULTS: The level of HSP60 protein was significantly associated with depth invasion, lymph node metastasis and stage of disease (all P<0.05). Both univariate and multivariate analyses revealed that HSP60 was an independent prognostic factor for both overall survival (OS) and recurrence-free survival (RFS) (both P<0.05). Furthermore, HSP60 overexpression was associated with a poor prognosis in patients with advanced gastric cancer in different risk groups. Moreover, HSP60 was significantly correlated with MMP-9 among 223 gastric cancer tissues (P<0.001). Patients who had HSP60 overexpression, in which tumor cells displayed high invasiveness, had poor OS and shorter RFS. CONCLUSION: HSP60 plays an important role on tumor aggressiveness and prognosis, and may act as a promising target for prognostic prediction. Public Library of Science 2014-09-10 /pmc/articles/PMC4160299/ /pubmed/25207654 http://dx.doi.org/10.1371/journal.pone.0107507 Text en © 2014 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Li, Xiao-shan Xu, Qing Fu, Xiang-yang Luo, Wei-sheng Heat Shock Protein 60 Overexpression Is Associated with the Progression and Prognosis in Gastric Cancer |
title | Heat Shock Protein 60 Overexpression Is Associated with the Progression and Prognosis in Gastric Cancer |
title_full | Heat Shock Protein 60 Overexpression Is Associated with the Progression and Prognosis in Gastric Cancer |
title_fullStr | Heat Shock Protein 60 Overexpression Is Associated with the Progression and Prognosis in Gastric Cancer |
title_full_unstemmed | Heat Shock Protein 60 Overexpression Is Associated with the Progression and Prognosis in Gastric Cancer |
title_short | Heat Shock Protein 60 Overexpression Is Associated with the Progression and Prognosis in Gastric Cancer |
title_sort | heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160299/ https://www.ncbi.nlm.nih.gov/pubmed/25207654 http://dx.doi.org/10.1371/journal.pone.0107507 |
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