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Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAF(V600E) inhibition and can be targeted to reduce resistance

In theory, pharmacological inhibition of oncogenic signaling is an effective strategy to halt cellular proliferation, induce apoptosis, and eliminate cancer cells. In practice, drugs (e.g., PLX-4032) that inhibit oncogenes like B-RAF(V600E) provide relatively short-term success in patients, due to a...

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Detalles Bibliográficos
Autores principales:	Serasinghe, Madhavika N., Missert, Derek J., Asciolla, James J., Wieder, Shira Y., Podgrabinska, Simona, Izadmehr, Sudeh, Belbin, Gillian, Skobe, Mihaela, Chipuk, Jerry E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160434/ https://www.ncbi.nlm.nih.gov/pubmed/24608435 http://dx.doi.org/10.1038/onc.2014.21

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