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Mdmx promotes genomic instability independent of p53 and Mdm2

The oncogene Mdmx is overexpressed in many human malignancies, and together with Mdm2, negatively regulates the p53 tumor suppressor. However, a p53-independent function of Mdmx that impacts genome stability has been described, but this function is not well understood. In the present study, we deter...

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Detalles Bibliográficos
Autores principales: Carrillo, Alexia M., Bouska, Alyssa, Arrate, Maria Pia, Eischen, Christine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160436/
https://www.ncbi.nlm.nih.gov/pubmed/24608433
http://dx.doi.org/10.1038/onc.2014.27