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Improved productivity of poly (4-hydroxybutyrate) (P4HB) in recombinant Escherichia coli using glycerol as the growth substrate with fed-batch culture
BACKGROUND: The most successful polyhydroxyalkanoate (PHA) in medical applications is poly(4-hydroxybutyrate) (P4HB), which is due to its biodegradability, biocompatibility and mechanical properties. One of the major obstacles for wider applications of P4HB is the cost of production and purification...
Autores principales: | Le Meur, Sylvaine, Zinn, Manfred, Egli, Thomas, Thöny-Meyer, Linda, Ren, Qun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160554/ https://www.ncbi.nlm.nih.gov/pubmed/25176327 http://dx.doi.org/10.1186/s12934-014-0131-2 |
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