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Diagnosis and Treatment of Adrenal Medullary Hyperplasia: Experience from 12 Cases
Objective. To dissect the characteristics of adrenal medullary hyperplasia (AMH) and share our experience of diagnosis and treatment of AMH. Methods. From 1999 to 2013, 12 cases of AMH have been pathologically diagnosed after operation in our hospital. The clinical characteristics, process of diagno...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160612/ https://www.ncbi.nlm.nih.gov/pubmed/25246937 http://dx.doi.org/10.1155/2014/752410 |
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author | Yang, Lu Gao, Liang Lv, Xiao Qian, Shengqiang Bu, Siyuan Wei, Qiang Yuan, Jiuhong Fan, Tianyong |
author_facet | Yang, Lu Gao, Liang Lv, Xiao Qian, Shengqiang Bu, Siyuan Wei, Qiang Yuan, Jiuhong Fan, Tianyong |
author_sort | Yang, Lu |
collection | PubMed |
description | Objective. To dissect the characteristics of adrenal medullary hyperplasia (AMH) and share our experience of diagnosis and treatment of AMH. Methods. From 1999 to 2013, 12 cases of AMH have been pathologically diagnosed after operation in our hospital. The clinical characteristics, process of diagnosis, treatment, and prognosis during follow-up of all patients are summarized retrospectively. Results. Four cases were trended to be AMH and 6 cases were trended to be pheochromocytoma before operation; moreover, the other two patients were diagnosed accidentally. All patients, except for the patient with mucinous tubular and spindle cell carcinoma of left kidney by open surgery, experienced a smooth laparoscopic adrenalectomy, including 2 with radical nephrectomy, 10 of which experienced unilateral adrenalectomy, 1 was bilaterally partial adrenalectomy, and the remaining one was unilaterally complete removal and then 2/3 partially contralateral excision. After a medium follow-up of 6.5 years, it demonstrated a satisfactory outcome of 8 cured patients and 4 symptomatic improved patients. Conclusions. AMH presents a mimicking morphology and clinical manifestation with pheochromocytoma. Surgery could be the only effective choice for the treatment of AMH and showed a preferable prognosis after a quite long follow-up. |
format | Online Article Text |
id | pubmed-4160612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41606122014-09-22 Diagnosis and Treatment of Adrenal Medullary Hyperplasia: Experience from 12 Cases Yang, Lu Gao, Liang Lv, Xiao Qian, Shengqiang Bu, Siyuan Wei, Qiang Yuan, Jiuhong Fan, Tianyong Int J Endocrinol Clinical Study Objective. To dissect the characteristics of adrenal medullary hyperplasia (AMH) and share our experience of diagnosis and treatment of AMH. Methods. From 1999 to 2013, 12 cases of AMH have been pathologically diagnosed after operation in our hospital. The clinical characteristics, process of diagnosis, treatment, and prognosis during follow-up of all patients are summarized retrospectively. Results. Four cases were trended to be AMH and 6 cases were trended to be pheochromocytoma before operation; moreover, the other two patients were diagnosed accidentally. All patients, except for the patient with mucinous tubular and spindle cell carcinoma of left kidney by open surgery, experienced a smooth laparoscopic adrenalectomy, including 2 with radical nephrectomy, 10 of which experienced unilateral adrenalectomy, 1 was bilaterally partial adrenalectomy, and the remaining one was unilaterally complete removal and then 2/3 partially contralateral excision. After a medium follow-up of 6.5 years, it demonstrated a satisfactory outcome of 8 cured patients and 4 symptomatic improved patients. Conclusions. AMH presents a mimicking morphology and clinical manifestation with pheochromocytoma. Surgery could be the only effective choice for the treatment of AMH and showed a preferable prognosis after a quite long follow-up. Hindawi Publishing Corporation 2014 2014-08-27 /pmc/articles/PMC4160612/ /pubmed/25246937 http://dx.doi.org/10.1155/2014/752410 Text en Copyright © 2014 Lu Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Yang, Lu Gao, Liang Lv, Xiao Qian, Shengqiang Bu, Siyuan Wei, Qiang Yuan, Jiuhong Fan, Tianyong Diagnosis and Treatment of Adrenal Medullary Hyperplasia: Experience from 12 Cases |
title | Diagnosis and Treatment of Adrenal Medullary Hyperplasia: Experience from 12 Cases |
title_full | Diagnosis and Treatment of Adrenal Medullary Hyperplasia: Experience from 12 Cases |
title_fullStr | Diagnosis and Treatment of Adrenal Medullary Hyperplasia: Experience from 12 Cases |
title_full_unstemmed | Diagnosis and Treatment of Adrenal Medullary Hyperplasia: Experience from 12 Cases |
title_short | Diagnosis and Treatment of Adrenal Medullary Hyperplasia: Experience from 12 Cases |
title_sort | diagnosis and treatment of adrenal medullary hyperplasia: experience from 12 cases |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160612/ https://www.ncbi.nlm.nih.gov/pubmed/25246937 http://dx.doi.org/10.1155/2014/752410 |
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