Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress

Green tea polyphenols are strong antioxidants and can reduce free radical damage. To investigate their neuroprotective potential, we induced oxidative damage in spinal cord neurons using hydrogen peroxide, and applied different concentrations (50–200 μg/mL) of green tea polyphenol to the cell medium...

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Autores principales: Zhao, Jianbo, Fang, Shiqiang, Yuan, Yajiang, Guo, Zhanpeng, Zeng, Jinhao, Guo, Yue, Tang, Peifu, Mei, Xifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Research and Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160869/
https://www.ncbi.nlm.nih.gov/pubmed/25221595
http://dx.doi.org/10.4103/1673-5374.137591
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author Zhao, Jianbo
Fang, Shiqiang
Yuan, Yajiang
Guo, Zhanpeng
Zeng, Jinhao
Guo, Yue
Tang, Peifu
Mei, Xifan
author_facet Zhao, Jianbo
Fang, Shiqiang
Yuan, Yajiang
Guo, Zhanpeng
Zeng, Jinhao
Guo, Yue
Tang, Peifu
Mei, Xifan
author_sort Zhao, Jianbo
collection PubMed
description Green tea polyphenols are strong antioxidants and can reduce free radical damage. To investigate their neuroprotective potential, we induced oxidative damage in spinal cord neurons using hydrogen peroxide, and applied different concentrations (50–200 μg/mL) of green tea polyphenol to the cell medium for 24 hours. Measurements of superoxide dismutase activity, malondialdehyde content, and expression of apoptosis-related genes and proteins revealed that green tea polyphenol effectively alleviated oxidative stress. Our results indicate that green tea polyphenols play a protective role in spinal cord neurons under oxidative stress.
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spelling pubmed-41608692014-09-14 Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress Zhao, Jianbo Fang, Shiqiang Yuan, Yajiang Guo, Zhanpeng Zeng, Jinhao Guo, Yue Tang, Peifu Mei, Xifan Neural Regen Res Research and Report Green tea polyphenols are strong antioxidants and can reduce free radical damage. To investigate their neuroprotective potential, we induced oxidative damage in spinal cord neurons using hydrogen peroxide, and applied different concentrations (50–200 μg/mL) of green tea polyphenol to the cell medium for 24 hours. Measurements of superoxide dismutase activity, malondialdehyde content, and expression of apoptosis-related genes and proteins revealed that green tea polyphenol effectively alleviated oxidative stress. Our results indicate that green tea polyphenols play a protective role in spinal cord neurons under oxidative stress. Medknow Publications & Media Pvt Ltd 2014-07-15 /pmc/articles/PMC4160869/ /pubmed/25221595 http://dx.doi.org/10.4103/1673-5374.137591 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report
Zhao, Jianbo
Fang, Shiqiang
Yuan, Yajiang
Guo, Zhanpeng
Zeng, Jinhao
Guo, Yue
Tang, Peifu
Mei, Xifan
Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress
title Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress
title_full Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress
title_fullStr Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress
title_full_unstemmed Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress
title_short Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress
title_sort green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress
topic Research and Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160869/
https://www.ncbi.nlm.nih.gov/pubmed/25221595
http://dx.doi.org/10.4103/1673-5374.137591
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