Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells

Although cholecystokinin octapeptide-8 is important for neurological function, its neuroprotective properties remain unclear. We speculated that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against oxidative injury. In this study, retinal pigment epithelial cells...

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Autores principales: Liu, Yuan, Zhang, Yueling, Gu, Zhaohui, Hao, Lina, Du, Juan, Yang, Qian, Li, Suping, Wang, Liying, Gong, Shilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Technical Updates
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160873/
https://www.ncbi.nlm.nih.gov/pubmed/25221599
http://dx.doi.org/10.4103/1673-5374.137596
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author Liu, Yuan
Zhang, Yueling
Gu, Zhaohui
Hao, Lina
Du, Juan
Yang, Qian
Li, Suping
Wang, Liying
Gong, Shilei
author_facet Liu, Yuan
Zhang, Yueling
Gu, Zhaohui
Hao, Lina
Du, Juan
Yang, Qian
Li, Suping
Wang, Liying
Gong, Shilei
author_sort Liu, Yuan
collection PubMed
description Although cholecystokinin octapeptide-8 is important for neurological function, its neuroprotective properties remain unclear. We speculated that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against oxidative injury. In this study, retinal pigment epithelial cells were treated with peroxynitrite to induce oxidative stress. Peroxynitrite triggered apoptosis in these cells, and increased the expression of Fas-associated death domain, Bax, caspa-se-8 and Bcl-2. These changes were suppressed by treatment with cholecystokinin octapeptide-8. These results suggest that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against apoptosis induced by peroxynitrite.
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spelling pubmed-41608732014-09-14 Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells Liu, Yuan Zhang, Yueling Gu, Zhaohui Hao, Lina Du, Juan Yang, Qian Li, Suping Wang, Liying Gong, Shilei Neural Regen Res Technical Updates Although cholecystokinin octapeptide-8 is important for neurological function, its neuroprotective properties remain unclear. We speculated that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against oxidative injury. In this study, retinal pigment epithelial cells were treated with peroxynitrite to induce oxidative stress. Peroxynitrite triggered apoptosis in these cells, and increased the expression of Fas-associated death domain, Bax, caspa-se-8 and Bcl-2. These changes were suppressed by treatment with cholecystokinin octapeptide-8. These results suggest that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against apoptosis induced by peroxynitrite. Medknow Publications & Media Pvt Ltd 2014-07-15 /pmc/articles/PMC4160873/ /pubmed/25221599 http://dx.doi.org/10.4103/1673-5374.137596 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technical Updates
Liu, Yuan
Zhang, Yueling
Gu, Zhaohui
Hao, Lina
Du, Juan
Yang, Qian
Li, Suping
Wang, Liying
Gong, Shilei
Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells
title Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells
title_full Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells
title_fullStr Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells
title_full_unstemmed Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells
title_short Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells
title_sort cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells
topic Technical Updates
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160873/
https://www.ncbi.nlm.nih.gov/pubmed/25221599
http://dx.doi.org/10.4103/1673-5374.137596
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