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Update on different aspects of HCV variability: focus on NS5B polymerase
The study of hepatitis C virus (HCV) genotypes/subtypes, quasispecies and recombinants obtained by virus genome sequencing are important for epidemiological studies, to trace the source of infection, for development of new direct acting antivirals (DAAs) therapy and for understanding antiviral selec...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160895/ https://www.ncbi.nlm.nih.gov/pubmed/25234810 http://dx.doi.org/10.1186/1471-2334-14-S5-S1 |
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author | Marascio, Nadia Torti, Carlo Liberto, Maria Carla Focà, Alfredo |
author_facet | Marascio, Nadia Torti, Carlo Liberto, Maria Carla Focà, Alfredo |
author_sort | Marascio, Nadia |
collection | PubMed |
description | The study of hepatitis C virus (HCV) genotypes/subtypes, quasispecies and recombinants obtained by virus genome sequencing are important for epidemiological studies, to trace the source of infection, for development of new direct acting antivirals (DAAs) therapy and for understanding antiviral selection pressures. The HCV NS5B gene encodes a polymerase, which is responsible for virus replication and is a potential target for the development of antiviral agents. Many studies for classification of HCV use a particular segment of the NS5B gene, in addition to other specific regions, and phylogenetic analysis. Actually, some nucleoside/nucleotide analogues and non-nucleoside inhibitors target NS5B protein. This review focuses on HCV variability, phylogenetic analysis and the role of NS5B in the virus-host interactions. |
format | Online Article Text |
id | pubmed-4160895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41608952014-09-25 Update on different aspects of HCV variability: focus on NS5B polymerase Marascio, Nadia Torti, Carlo Liberto, Maria Carla Focà, Alfredo BMC Infect Dis Review The study of hepatitis C virus (HCV) genotypes/subtypes, quasispecies and recombinants obtained by virus genome sequencing are important for epidemiological studies, to trace the source of infection, for development of new direct acting antivirals (DAAs) therapy and for understanding antiviral selection pressures. The HCV NS5B gene encodes a polymerase, which is responsible for virus replication and is a potential target for the development of antiviral agents. Many studies for classification of HCV use a particular segment of the NS5B gene, in addition to other specific regions, and phylogenetic analysis. Actually, some nucleoside/nucleotide analogues and non-nucleoside inhibitors target NS5B protein. This review focuses on HCV variability, phylogenetic analysis and the role of NS5B in the virus-host interactions. BioMed Central 2014-09-05 /pmc/articles/PMC4160895/ /pubmed/25234810 http://dx.doi.org/10.1186/1471-2334-14-S5-S1 Text en Copyright © 2014 Marascio et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Marascio, Nadia Torti, Carlo Liberto, Maria Carla Focà, Alfredo Update on different aspects of HCV variability: focus on NS5B polymerase |
title | Update on different aspects of HCV variability: focus on NS5B polymerase |
title_full | Update on different aspects of HCV variability: focus on NS5B polymerase |
title_fullStr | Update on different aspects of HCV variability: focus on NS5B polymerase |
title_full_unstemmed | Update on different aspects of HCV variability: focus on NS5B polymerase |
title_short | Update on different aspects of HCV variability: focus on NS5B polymerase |
title_sort | update on different aspects of hcv variability: focus on ns5b polymerase |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160895/ https://www.ncbi.nlm.nih.gov/pubmed/25234810 http://dx.doi.org/10.1186/1471-2334-14-S5-S1 |
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