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Update on different aspects of HCV variability: focus on NS5B polymerase

The study of hepatitis C virus (HCV) genotypes/subtypes, quasispecies and recombinants obtained by virus genome sequencing are important for epidemiological studies, to trace the source of infection, for development of new direct acting antivirals (DAAs) therapy and for understanding antiviral selec...

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Detalles Bibliográficos
Autores principales: Marascio, Nadia, Torti, Carlo, Liberto, Maria Carla, Focà, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160895/
https://www.ncbi.nlm.nih.gov/pubmed/25234810
http://dx.doi.org/10.1186/1471-2334-14-S5-S1
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author Marascio, Nadia
Torti, Carlo
Liberto, Maria Carla
Focà, Alfredo
author_facet Marascio, Nadia
Torti, Carlo
Liberto, Maria Carla
Focà, Alfredo
author_sort Marascio, Nadia
collection PubMed
description The study of hepatitis C virus (HCV) genotypes/subtypes, quasispecies and recombinants obtained by virus genome sequencing are important for epidemiological studies, to trace the source of infection, for development of new direct acting antivirals (DAAs) therapy and for understanding antiviral selection pressures. The HCV NS5B gene encodes a polymerase, which is responsible for virus replication and is a potential target for the development of antiviral agents. Many studies for classification of HCV use a particular segment of the NS5B gene, in addition to other specific regions, and phylogenetic analysis. Actually, some nucleoside/nucleotide analogues and non-nucleoside inhibitors target NS5B protein. This review focuses on HCV variability, phylogenetic analysis and the role of NS5B in the virus-host interactions.
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spelling pubmed-41608952014-09-25 Update on different aspects of HCV variability: focus on NS5B polymerase Marascio, Nadia Torti, Carlo Liberto, Maria Carla Focà, Alfredo BMC Infect Dis Review The study of hepatitis C virus (HCV) genotypes/subtypes, quasispecies and recombinants obtained by virus genome sequencing are important for epidemiological studies, to trace the source of infection, for development of new direct acting antivirals (DAAs) therapy and for understanding antiviral selection pressures. The HCV NS5B gene encodes a polymerase, which is responsible for virus replication and is a potential target for the development of antiviral agents. Many studies for classification of HCV use a particular segment of the NS5B gene, in addition to other specific regions, and phylogenetic analysis. Actually, some nucleoside/nucleotide analogues and non-nucleoside inhibitors target NS5B protein. This review focuses on HCV variability, phylogenetic analysis and the role of NS5B in the virus-host interactions. BioMed Central 2014-09-05 /pmc/articles/PMC4160895/ /pubmed/25234810 http://dx.doi.org/10.1186/1471-2334-14-S5-S1 Text en Copyright © 2014 Marascio et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Marascio, Nadia
Torti, Carlo
Liberto, Maria Carla
Focà, Alfredo
Update on different aspects of HCV variability: focus on NS5B polymerase
title Update on different aspects of HCV variability: focus on NS5B polymerase
title_full Update on different aspects of HCV variability: focus on NS5B polymerase
title_fullStr Update on different aspects of HCV variability: focus on NS5B polymerase
title_full_unstemmed Update on different aspects of HCV variability: focus on NS5B polymerase
title_short Update on different aspects of HCV variability: focus on NS5B polymerase
title_sort update on different aspects of hcv variability: focus on ns5b polymerase
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160895/
https://www.ncbi.nlm.nih.gov/pubmed/25234810
http://dx.doi.org/10.1186/1471-2334-14-S5-S1
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