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Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis

Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation, and fibrosis and is believed to develop via a “two-hit process”; however, its pathophysiology remains unclear. Fibroblast growth factors (FGFs) are heparin-binding polypeptides with diverse biological a...

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Autores principales: Hanaka, Hiromi, Hamada, Tsuyoshi, Ito, Masataka, Nakashima, Hiroyuki, Tomita, Kengo, Seki, Shuhji, Kobayashi, Yasushi, Imaki, Junko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160928/
https://www.ncbi.nlm.nih.gov/pubmed/24521867
http://dx.doi.org/10.1538/expanim.63.85
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author Hanaka, Hiromi
Hamada, Tsuyoshi
Ito, Masataka
Nakashima, Hiroyuki
Tomita, Kengo
Seki, Shuhji
Kobayashi, Yasushi
Imaki, Junko
author_facet Hanaka, Hiromi
Hamada, Tsuyoshi
Ito, Masataka
Nakashima, Hiroyuki
Tomita, Kengo
Seki, Shuhji
Kobayashi, Yasushi
Imaki, Junko
author_sort Hanaka, Hiromi
collection PubMed
description Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation, and fibrosis and is believed to develop via a “two-hit process”; however, its pathophysiology remains unclear. Fibroblast growth factors (FGFs) are heparin-binding polypeptides with diverse biological activities in many developmental and metabolic processes. In particular, FGF5 is associated with high blood pressure. We investigated the function of FGF5 in vivo using spontaneously Fgf5 null mice and explored the role of diet in the development of NASH. Mice fed a high-fat diet gained little weight and had higher serum alanine transaminase, aspartate amino transferase, and non–high-density lipoprotein-cholesterol levels. Liver histology indicated marked inflammation, focal necrosis, fat deposition, and fibrosis, similar to the characteristics of NASH. FGF5 and a high-fat diet play significant roles in the pathophysiology of hepatic fibrosis and Fgf5 null mice may provide a suitable model for liver fibrosis or NASH.
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spelling pubmed-41609282014-10-21 Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis Hanaka, Hiromi Hamada, Tsuyoshi Ito, Masataka Nakashima, Hiroyuki Tomita, Kengo Seki, Shuhji Kobayashi, Yasushi Imaki, Junko Exp Anim Original Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation, and fibrosis and is believed to develop via a “two-hit process”; however, its pathophysiology remains unclear. Fibroblast growth factors (FGFs) are heparin-binding polypeptides with diverse biological activities in many developmental and metabolic processes. In particular, FGF5 is associated with high blood pressure. We investigated the function of FGF5 in vivo using spontaneously Fgf5 null mice and explored the role of diet in the development of NASH. Mice fed a high-fat diet gained little weight and had higher serum alanine transaminase, aspartate amino transferase, and non–high-density lipoprotein-cholesterol levels. Liver histology indicated marked inflammation, focal necrosis, fat deposition, and fibrosis, similar to the characteristics of NASH. FGF5 and a high-fat diet play significant roles in the pathophysiology of hepatic fibrosis and Fgf5 null mice may provide a suitable model for liver fibrosis or NASH. Japanese Association for Laboratory Animal Science 2014-02-07 2014 /pmc/articles/PMC4160928/ /pubmed/24521867 http://dx.doi.org/10.1538/expanim.63.85 Text en ©2014 Japanese Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Original
Hanaka, Hiromi
Hamada, Tsuyoshi
Ito, Masataka
Nakashima, Hiroyuki
Tomita, Kengo
Seki, Shuhji
Kobayashi, Yasushi
Imaki, Junko
Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis
title Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis
title_full Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis
title_fullStr Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis
title_full_unstemmed Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis
title_short Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis
title_sort fibroblast growth factor-5 participates in the progression of hepatic fibrosis
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160928/
https://www.ncbi.nlm.nih.gov/pubmed/24521867
http://dx.doi.org/10.1538/expanim.63.85
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