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Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis
Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation, and fibrosis and is believed to develop via a “two-hit process”; however, its pathophysiology remains unclear. Fibroblast growth factors (FGFs) are heparin-binding polypeptides with diverse biological a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Association for Laboratory Animal Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160928/ https://www.ncbi.nlm.nih.gov/pubmed/24521867 http://dx.doi.org/10.1538/expanim.63.85 |
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author | Hanaka, Hiromi Hamada, Tsuyoshi Ito, Masataka Nakashima, Hiroyuki Tomita, Kengo Seki, Shuhji Kobayashi, Yasushi Imaki, Junko |
author_facet | Hanaka, Hiromi Hamada, Tsuyoshi Ito, Masataka Nakashima, Hiroyuki Tomita, Kengo Seki, Shuhji Kobayashi, Yasushi Imaki, Junko |
author_sort | Hanaka, Hiromi |
collection | PubMed |
description | Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation, and fibrosis and is believed to develop via a “two-hit process”; however, its pathophysiology remains unclear. Fibroblast growth factors (FGFs) are heparin-binding polypeptides with diverse biological activities in many developmental and metabolic processes. In particular, FGF5 is associated with high blood pressure. We investigated the function of FGF5 in vivo using spontaneously Fgf5 null mice and explored the role of diet in the development of NASH. Mice fed a high-fat diet gained little weight and had higher serum alanine transaminase, aspartate amino transferase, and non–high-density lipoprotein-cholesterol levels. Liver histology indicated marked inflammation, focal necrosis, fat deposition, and fibrosis, similar to the characteristics of NASH. FGF5 and a high-fat diet play significant roles in the pathophysiology of hepatic fibrosis and Fgf5 null mice may provide a suitable model for liver fibrosis or NASH. |
format | Online Article Text |
id | pubmed-4160928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41609282014-10-21 Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis Hanaka, Hiromi Hamada, Tsuyoshi Ito, Masataka Nakashima, Hiroyuki Tomita, Kengo Seki, Shuhji Kobayashi, Yasushi Imaki, Junko Exp Anim Original Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation, and fibrosis and is believed to develop via a “two-hit process”; however, its pathophysiology remains unclear. Fibroblast growth factors (FGFs) are heparin-binding polypeptides with diverse biological activities in many developmental and metabolic processes. In particular, FGF5 is associated with high blood pressure. We investigated the function of FGF5 in vivo using spontaneously Fgf5 null mice and explored the role of diet in the development of NASH. Mice fed a high-fat diet gained little weight and had higher serum alanine transaminase, aspartate amino transferase, and non–high-density lipoprotein-cholesterol levels. Liver histology indicated marked inflammation, focal necrosis, fat deposition, and fibrosis, similar to the characteristics of NASH. FGF5 and a high-fat diet play significant roles in the pathophysiology of hepatic fibrosis and Fgf5 null mice may provide a suitable model for liver fibrosis or NASH. Japanese Association for Laboratory Animal Science 2014-02-07 2014 /pmc/articles/PMC4160928/ /pubmed/24521867 http://dx.doi.org/10.1538/expanim.63.85 Text en ©2014 Japanese Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Original Hanaka, Hiromi Hamada, Tsuyoshi Ito, Masataka Nakashima, Hiroyuki Tomita, Kengo Seki, Shuhji Kobayashi, Yasushi Imaki, Junko Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis |
title | Fibroblast Growth Factor-5 Participates in the Progression of Hepatic
Fibrosis |
title_full | Fibroblast Growth Factor-5 Participates in the Progression of Hepatic
Fibrosis |
title_fullStr | Fibroblast Growth Factor-5 Participates in the Progression of Hepatic
Fibrosis |
title_full_unstemmed | Fibroblast Growth Factor-5 Participates in the Progression of Hepatic
Fibrosis |
title_short | Fibroblast Growth Factor-5 Participates in the Progression of Hepatic
Fibrosis |
title_sort | fibroblast growth factor-5 participates in the progression of hepatic
fibrosis |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160928/ https://www.ncbi.nlm.nih.gov/pubmed/24521867 http://dx.doi.org/10.1538/expanim.63.85 |
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