Cargando…
Natural Killer T Cells in Adipose Tissue Are Activated in Lean Mice
Adipose tissues are closely connected with the immune system. It has been suggested that metabolic syndromes such as type 2 diabetes, arteriosclerosis and liver steatosis can be attributed to adipose tissue inflammation characterized by macrophage infiltration. To understand a physiological and path...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Association for Laboratory Animal Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160955/ https://www.ncbi.nlm.nih.gov/pubmed/24172196 http://dx.doi.org/10.1538/expanim.62.319 |
_version_ | 1782334474954997760 |
---|---|
author | Kondo, Taisuke Toyoshima, Yujiro Ishii, Yoshiyuki Kyuwa, Shigeru |
author_facet | Kondo, Taisuke Toyoshima, Yujiro Ishii, Yoshiyuki Kyuwa, Shigeru |
author_sort | Kondo, Taisuke |
collection | PubMed |
description | Adipose tissues are closely connected with the immune system. It has been suggested that metabolic syndromes such as type 2 diabetes, arteriosclerosis and liver steatosis can be attributed to adipose tissue inflammation characterized by macrophage infiltration. To understand a physiological and pathological role of natural killer T (NKT) cells on inflammation in adipose tissue, we characterized a subset of NKT cells in abdominal and subcutaneous adipose tissues in C57BL/6J mice fed normal or high-fat diets. NKT cells comprised a larger portion of lymphocytes in adipose tissues compared with the spleen and peripheral blood, with epididymal adipose tissue having the highest number of NKT cells. Furthermore, some NKT cells in adipose tissues expressed higher levels of CD69 and intracellular interferon-γ, whereas the Vβ repertoires of NKT cells in adipose tissues were similar to other cells. In obese mice fed a high-fat diet, adipose tissue inflammation had little effect on the Vβ repertoire of NKT cells in epididymal adipose tissues. We speculate that the NKT cells in adipose tissues may form an equivalent subset in other tissues and that these subsets are likely to participate in adipose tissue inflammation. Additionally, the high expression level of CD69 and intracellular IFN-γ raises the possibility that NKT cells in adipose tissue may be stimulated by some physiological mechanism. |
format | Online Article Text |
id | pubmed-4160955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41609552014-10-21 Natural Killer T Cells in Adipose Tissue Are Activated in Lean Mice Kondo, Taisuke Toyoshima, Yujiro Ishii, Yoshiyuki Kyuwa, Shigeru Exp Anim Original Adipose tissues are closely connected with the immune system. It has been suggested that metabolic syndromes such as type 2 diabetes, arteriosclerosis and liver steatosis can be attributed to adipose tissue inflammation characterized by macrophage infiltration. To understand a physiological and pathological role of natural killer T (NKT) cells on inflammation in adipose tissue, we characterized a subset of NKT cells in abdominal and subcutaneous adipose tissues in C57BL/6J mice fed normal or high-fat diets. NKT cells comprised a larger portion of lymphocytes in adipose tissues compared with the spleen and peripheral blood, with epididymal adipose tissue having the highest number of NKT cells. Furthermore, some NKT cells in adipose tissues expressed higher levels of CD69 and intracellular interferon-γ, whereas the Vβ repertoires of NKT cells in adipose tissues were similar to other cells. In obese mice fed a high-fat diet, adipose tissue inflammation had little effect on the Vβ repertoire of NKT cells in epididymal adipose tissues. We speculate that the NKT cells in adipose tissues may form an equivalent subset in other tissues and that these subsets are likely to participate in adipose tissue inflammation. Additionally, the high expression level of CD69 and intracellular IFN-γ raises the possibility that NKT cells in adipose tissue may be stimulated by some physiological mechanism. Japanese Association for Laboratory Animal Science 2013-10-31 2013 /pmc/articles/PMC4160955/ /pubmed/24172196 http://dx.doi.org/10.1538/expanim.62.319 Text en ©2013 Japanese Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Original Kondo, Taisuke Toyoshima, Yujiro Ishii, Yoshiyuki Kyuwa, Shigeru Natural Killer T Cells in Adipose Tissue Are Activated in Lean Mice |
title | Natural Killer T Cells in Adipose Tissue Are Activated in Lean
Mice |
title_full | Natural Killer T Cells in Adipose Tissue Are Activated in Lean
Mice |
title_fullStr | Natural Killer T Cells in Adipose Tissue Are Activated in Lean
Mice |
title_full_unstemmed | Natural Killer T Cells in Adipose Tissue Are Activated in Lean
Mice |
title_short | Natural Killer T Cells in Adipose Tissue Are Activated in Lean
Mice |
title_sort | natural killer t cells in adipose tissue are activated in lean
mice |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160955/ https://www.ncbi.nlm.nih.gov/pubmed/24172196 http://dx.doi.org/10.1538/expanim.62.319 |
work_keys_str_mv | AT kondotaisuke naturalkillertcellsinadiposetissueareactivatedinleanmice AT toyoshimayujiro naturalkillertcellsinadiposetissueareactivatedinleanmice AT ishiiyoshiyuki naturalkillertcellsinadiposetissueareactivatedinleanmice AT kyuwashigeru naturalkillertcellsinadiposetissueareactivatedinleanmice |