Compound Heterozygosity of the Functionally Null Cdh23(v-ngt) and Hypomorphic Cdh23(ahl) Alleles Leads to Early-onset Progressive Hearing Loss in Mice

The waltzer (v) mouse mutant harbors a mutation in Cadherin 23 (Cdh23) and is a model for Usher syndrome type 1D, which is characterized by congenital deafness, vestibular dysfunction, and prepubertal onset of progressive retinitis pigmentosa. In mice, functionally null Cdh23 mutations affect stereo...

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Detalles Bibliográficos
Autores principales: Miyasaka, Yuki, Suzuki, Sari, Ohshiba, Yasuhiro, Watanabe, Kei, Sagara, Yoshihiko, Yasuda, Shumpei P., Matsuoka, Kunie, Shitara, Hiroshi, Yonekawa, Hiromichi, Kominami, Ryo, Kikkawa, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2013
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160959/
https://www.ncbi.nlm.nih.gov/pubmed/24172198
http://dx.doi.org/10.1538/expanim.62.333

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