Cargando…

Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes

There is increasing evidence that deficient clearance of β-amyloid (Aβ) contributes to its accumulation in late-onset Alzheimer disease (AD). Several Aβ-degrading enzymes, including neprilysin (NEP), endothelin-converting enzyme (ECE), and angiotensin-converting enzyme (ACE) reduce Aβ levels and pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miners, J. Scott, Palmer, Jennifer C., Tayler, Hannah, Palmer, Laura E., Ashby, Emma, Kehoe, Patrick G., Love, Seth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160973/ https://www.ncbi.nlm.nih.gov/pubmed/25309424 http://dx.doi.org/10.3389/fnagi.2014.00238

Ejemplares similares

Zibotentan, an Endothelin A Receptor Antagonist, Prevents Amyloid-β-Induced Hypertension and Maintains Cerebral Perfusion
por: Palmer, Jennifer C., et al.
Publicado: (2020)

Elevated late-life blood pressure may maintain brain oxygenation and slow amyloid-β accumulation at the expense of cerebral vascular damage
por: Tayler, Hannah M, et al.
Publicado: (2023)

Mediators of cerebral hypoperfusion and blood‐brain barrier leakiness in Alzheimer’s disease, vascular dementia and mixed dementia
por: Tayler, Hannah, et al.
Publicado: (2021)

Pathophysiology of white matter perfusion in Alzheimer’s disease and vascular dementia
por: Barker, Rachel, et al.
Publicado: (2014)

Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology
por: Kehoe, Patrick Gavin, et al.
Publicado: (2016)

Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1
por: Miners, J Scott, et al.
Publicado: (2014)

Cognitive impact of COVID-19: looking beyond the short term
por: Miners, Scott, et al.
Publicado: (2020)

Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease
por: Miners, J. Scott, et al.
Publicado: (2015)

Pathological changes within the cerebral vasculature in Alzheimer’s disease: New perspectives
por: Fisher, Robert A., et al.
Publicado: (2022)

Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer’s disease
por: AL Mulhim, Noura S., et al.
Publicado: (2019)

Pericyte Contractile Responses to Endothelin-1 and Aβ Peptides: Assessment by Electrical Impedance Assay
por: Hibbs, Elliott, et al.
Publicado: (2021)

Differing associations between Aβ accumulation, hypoperfusion, blood–brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease
por: Miners, J Scott, et al.
Publicado: (2017)

Prion Protein Is Decreased in Alzheimer's Brain and Inversely Correlates with BACE1 Activity, Amyloid-β Levels and Braak Stage
por: Whitehouse, Isobel J., et al.
Publicado: (2013)

Cerebrovascular disease in ageing and Alzheimer’s disease
por: Love, Seth, et al.
Publicado: (2015)

Degrading Ochratoxin A and Zearalenone Mycotoxins Using a Multifunctional Recombinant Enzyme
por: Azam, Md Shofiul, et al.
Publicado: (2019)

Synaptic protein levels altered in vascular dementia
por: Sinclair, Lindsey I, et al.
Publicado: (2015)

BIN1 Is Decreased in Sporadic but Not Familial Alzheimer’s Disease or in Aging
por: Glennon, Elizabeth B. C., et al.
Publicado: (2013)

Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson’s disease
por: Swirski, Marta, et al.
Publicado: (2014)

CSF evidence of pericyte damage in Alzheimer’s disease is associated with markers of blood-brain barrier dysfunction and disease pathology
por: Miners, J. S., et al.
Publicado: (2019)

The biogenesis of β-lactamase enzymes
por: Kaderabkova, Nikol, et al.
Publicado: (2022)

Dysregulation of ACE-1 in Normal Aging and the Early Stages of Alzheimer’s Disease
por: MacLachlan, Robert, et al.
Publicado: (2022)

Metatranscriptome Analysis Deciphers Multifunctional Genes and Enzymes Linked With the Degradation of Aromatic Compounds and Pesticides in the Wheat Rhizosphere
por: Singh, Dhananjaya P., et al.
Publicado: (2018)

Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer’s disease
por: Asby, Daniel, et al.
Publicado: (2021)

A Multifunctional Polysaccharide Utilization Gene Cluster in Colwellia echini Encodes Enzymes for the Complete Degradation of κ-Carrageenan, ι-Carrageenan, and Hybrid β/κ-Carrageenan
por: Christiansen, Line, et al.
Publicado: (2020)

Cerebral perfusion in sepsis
por: Burkhart, Christoph S, et al.
Publicado: (2010)

Plant tRNA ligases are multifunctional enzymes that have diverged in sequence and substrate specificity from RNA ligases of other phylogenetic origins
por: Englert, Markus, et al.
Publicado: (2005)

Multifunctional elastin-like polypeptide renders β-glucosidase enzyme phase transition and high stability
por: Zhou, Yang, et al.
Publicado: (2019)

Human metallo-β-lactamase enzymes degrade penicillin
por: Diene, Seydina M., et al.
Publicado: (2019)

A Global Characterization and Identification of Multifunctional Enzymes
por: Cheng, Xian-Ying, et al.
Publicado: (2012)

Cysteinyl Cathepsins: Multifunctional Enzymes in Cardiovascular Disease
por: Li, Xiang, et al.
Publicado: (2012)

Divergence and Convergence in Enzyme Evolution
por: Galperin, Michael Y., et al.
Publicado: (2012)

The association of angiotensin-converting enzyme with biomarkers for Alzheimer’s disease
por: Jochemsen, Hadassa M, et al.
Publicado: (2014)

Multifunctional degradable electronic scaffolds for cardiac tissue engineering
por: Feiner, Ron, et al.
Publicado: (2018)

Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8(+) TCR-Vβ(+) expansions
por: Lissina, Anna, et al.
Publicado: (2018)

Cerebral perfusion in untreated, controlled, and uncontrolled hypertension
por: Christie, Isabel N, et al.
Publicado: (2022)

Cerebral Perfusion in Hemodialysis Patients: A Feasibility Study
por: Vanderlinden, Jessica Anne, et al.
Publicado: (2021)

Cerebral Perfusion and Cerebral Autoregulation after Cardiac Arrest
por: van den Brule, J. M. D., et al.
Publicado: (2018)

Activators and inhibitors of the plasminogen system in Alzheimer’s disease
por: Barker, Rachel, et al.
Publicado: (2012)

Enzymes of early-diverging, zoosporic fungi
por: Lange, Lene, et al.
Publicado: (2019)

Cerebral perfusion in sepsis-associated delirium
por: Pfister, David, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_b8emalcsor1e835thfco1pmtct