Automated synthesis of backbone protected peptides

The synthesis of peptides rich in aggregation prone sequences can be improved with backbone protection. We report the automated introduction of backbone protection to a peptide. This new method was applied in a fully-automated synthesis, giving improved handling, quality and yield of several challen...

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Detalles Bibliográficos
Autores principales: Abdel-Aal, Abu-Baker M., Papageorgiou, George, Quibell, Martin, Offer, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2014
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161149/
https://www.ncbi.nlm.nih.gov/pubmed/24938489
http://dx.doi.org/10.1039/c4cc03065f
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author Abdel-Aal, Abu-Baker M.
Papageorgiou, George
Quibell, Martin
Offer, John
author_facet Abdel-Aal, Abu-Baker M.
Papageorgiou, George
Quibell, Martin
Offer, John
author_sort Abdel-Aal, Abu-Baker M.
collection PubMed
description The synthesis of peptides rich in aggregation prone sequences can be improved with backbone protection. We report the automated introduction of backbone protection to a peptide. This new method was applied in a fully-automated synthesis, giving improved handling, quality and yield of several challenging target sequences.
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spelling pubmed-41611492014-09-22 Automated synthesis of backbone protected peptides Abdel-Aal, Abu-Baker M. Papageorgiou, George Quibell, Martin Offer, John Chem Commun (Camb) Chemistry The synthesis of peptides rich in aggregation prone sequences can be improved with backbone protection. We report the automated introduction of backbone protection to a peptide. This new method was applied in a fully-automated synthesis, giving improved handling, quality and yield of several challenging target sequences. Royal Society of Chemistry 2014-08-07 2014-06-18 /pmc/articles/PMC4161149/ /pubmed/24938489 http://dx.doi.org/10.1039/c4cc03065f Text en This journal is © The Royal Society of Chemistry 2014 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Abdel-Aal, Abu-Baker M.
Papageorgiou, George
Quibell, Martin
Offer, John
Automated synthesis of backbone protected peptides
title Automated synthesis of backbone protected peptides
title_full Automated synthesis of backbone protected peptides
title_fullStr Automated synthesis of backbone protected peptides
title_full_unstemmed Automated synthesis of backbone protected peptides
title_short Automated synthesis of backbone protected peptides
title_sort automated synthesis of backbone protected peptides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161149/
https://www.ncbi.nlm.nih.gov/pubmed/24938489
http://dx.doi.org/10.1039/c4cc03065f
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