The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity

[Image: see text] A facile route to perillyl alcohol (POH) differential glycosylation and the corresponding synthesis of a set of 34 POH glycosides is reported. Subsequent in vitro studies revealed a sugar dependent antiproliferative activity and the inhibition of S6 ribosomal protein phosphorylatio...

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Autores principales: Nandurkar, Nitin S., Zhang, Jianjun, Ye, Qing, Ponomareva, Larissa V., She, Qing-Bai, Thorson, Jon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161159/
https://www.ncbi.nlm.nih.gov/pubmed/25121720
http://dx.doi.org/10.1021/jm500870u
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author Nandurkar, Nitin S.
Zhang, Jianjun
Ye, Qing
Ponomareva, Larissa V.
She, Qing-Bai
Thorson, Jon S.
author_facet Nandurkar, Nitin S.
Zhang, Jianjun
Ye, Qing
Ponomareva, Larissa V.
She, Qing-Bai
Thorson, Jon S.
author_sort Nandurkar, Nitin S.
collection PubMed
description [Image: see text] A facile route to perillyl alcohol (POH) differential glycosylation and the corresponding synthesis of a set of 34 POH glycosides is reported. Subsequent in vitro studies revealed a sugar dependent antiproliferative activity and the inhibition of S6 ribosomal protein phosphorylation as a putative mechanism of representative POH glycosides. The most active glycoside from this cumulative study (4′-azido-d-glucoside, PG9) represents one of the most cytotoxic POH analogues reported to date.
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spelling pubmed-41611592015-08-14 The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity Nandurkar, Nitin S. Zhang, Jianjun Ye, Qing Ponomareva, Larissa V. She, Qing-Bai Thorson, Jon S. J Med Chem [Image: see text] A facile route to perillyl alcohol (POH) differential glycosylation and the corresponding synthesis of a set of 34 POH glycosides is reported. Subsequent in vitro studies revealed a sugar dependent antiproliferative activity and the inhibition of S6 ribosomal protein phosphorylation as a putative mechanism of representative POH glycosides. The most active glycoside from this cumulative study (4′-azido-d-glucoside, PG9) represents one of the most cytotoxic POH analogues reported to date. American Chemical Society 2014-08-14 2014-09-11 /pmc/articles/PMC4161159/ /pubmed/25121720 http://dx.doi.org/10.1021/jm500870u Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Nandurkar, Nitin S.
Zhang, Jianjun
Ye, Qing
Ponomareva, Larissa V.
She, Qing-Bai
Thorson, Jon S.
The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity
title The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity
title_full The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity
title_fullStr The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity
title_full_unstemmed The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity
title_short The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity
title_sort identification of perillyl alcohol glycosides with improved antiproliferative activity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161159/
https://www.ncbi.nlm.nih.gov/pubmed/25121720
http://dx.doi.org/10.1021/jm500870u
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