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Structural basis of IFNα receptor recognition by TYK2

Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family of non-receptor tyrosine kinases, which are essential for proper signaling in immune responses and development. Here we present a 2.0 angstrom resolution crystal structure of a receptor-binding fragment of human TYK2 encompassing...

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Detalles Bibliográficos
Autores principales:	Wallweber, Heidi J.A., Tam, Christine, Franke, Yvonne, Starovasnik, Melissa A., Lupardus, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161281/ https://www.ncbi.nlm.nih.gov/pubmed/24704786 http://dx.doi.org/10.1038/nsmb.2807

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