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Hydroxymethylated Cytosines Are Associated with Elevated C to G Transversion Rates
It has long been known that methylated cytosines deaminate at higher rates than unmodified cytosines and constitute mutational hotspots in mammalian genomes. The repertoire of naturally occurring cytosine modifications, however, extends beyond 5-methylcytosine to include its oxidation derivatives, n...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161303/ https://www.ncbi.nlm.nih.gov/pubmed/25211471 http://dx.doi.org/10.1371/journal.pgen.1004585 |