Muscular Dystrophy-Associated SUN1 and SUN2 Variants Disrupt Nuclear-Cytoskeletal Connections and Myonuclear Organization

Proteins of the nuclear envelope (NE) are associated with a range of inherited disorders, most commonly involving muscular dystrophy and cardiomyopathy, as exemplified by Emery-Dreifuss muscular dystrophy (EDMD). EDMD is both genetically and phenotypically variable, and some evidence of modifier gen...

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Detalles Bibliográficos
Autores principales: Meinke, Peter, Mattioli, Elisabetta, Haque, Farhana, Antoku, Susumu, Columbaro, Marta, Straatman, Kees R., Worman, Howard J., Gundersen, Gregg G., Lattanzi, Giovanna, Wehnert, Manfred, Shackleton, Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161305/
https://www.ncbi.nlm.nih.gov/pubmed/25210889
http://dx.doi.org/10.1371/journal.pgen.1004605

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