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Sterile Immunity to Malaria after DNA Prime/Adenovirus Boost Immunization Is Associated with Effector Memory CD8+T Cells Targeting AMA1 Class I Epitopes

BACKGROUND: Fifteen volunteers were immunized with three doses of plasmid DNA encoding P. falciparum circumsporozoite protein (CSP) and apical membrane antigen-1 (AMA1) and boosted with human adenovirus-5 (Ad) expressing the same antigens (DNA/Ad). Four volunteers (27%) demonstrated sterile immunity...

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Detalles Bibliográficos
Autores principales:	Sedegah, Martha, Hollingdale, Michael R., Farooq, Fouzia, Ganeshan, Harini, Belmonte, Maria, Kim, Yohan, Peters, Bjoern, Sette, Alessandro, Huang, Jun, McGrath, Shannon, Abot, Esteban, Limbach, Keith, Shi, Meng, Soisson, Lorraine, Diggs, Carter, Chuang, Ilin, Tamminga, Cindy, Epstein, Judith E., Villasante, Eileen, Richie, Thomas L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161338/ https://www.ncbi.nlm.nih.gov/pubmed/25211344 http://dx.doi.org/10.1371/journal.pone.0106241

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