Surgical Outcomes and Prognostic Factors of T4 Gastric Cancer Patients without Distant Metastasis

OBJECTIVE: To evaluate surgical outcomes and prognostic factors for T4 gastric cancer treated with curative resection. METHODS: Between January 1994 and December 2008, 94 patients diagnosed with histological T4 gastric carcinoma and treated with curative resection were recruited. Patient characteris...

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Autores principales: Li, Ming-zhe, Deng, Liang, Wang, Jing-jing, Xiao, Long-bin, Wu, Wen-hui, Yang, Shi-bin, Li, Wen-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161379/
https://www.ncbi.nlm.nih.gov/pubmed/25211331
http://dx.doi.org/10.1371/journal.pone.0107061
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author Li, Ming-zhe
Deng, Liang
Wang, Jing-jing
Xiao, Long-bin
Wu, Wen-hui
Yang, Shi-bin
Li, Wen-feng
author_facet Li, Ming-zhe
Deng, Liang
Wang, Jing-jing
Xiao, Long-bin
Wu, Wen-hui
Yang, Shi-bin
Li, Wen-feng
author_sort Li, Ming-zhe
collection PubMed
description OBJECTIVE: To evaluate surgical outcomes and prognostic factors for T4 gastric cancer treated with curative resection. METHODS: Between January 1994 and December 2008, 94 patients diagnosed with histological T4 gastric carcinoma and treated with curative resection were recruited. Patient characteristics, surgical complications, survival, and prognostic factors were analyzed. RESULTS: Postoperative morbidity and mortality were 18.1% and 2.1%, respectively. Multivariate analysis indicated lymph node metastasis (hazard ratio, 2.496; 95% confidence interval, 1.218–5.115; p = 0.012) was independent prognostic factor. CONCLUSIONS: For patients with T4 gastric cancer, lymph node metastasis was associated with poorer survival. Neoadjuvant chemotherapy or aggressive adjuvant chemotherapy after radical resection was strongly recommended for these patients.
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spelling pubmed-41613792014-09-17 Surgical Outcomes and Prognostic Factors of T4 Gastric Cancer Patients without Distant Metastasis Li, Ming-zhe Deng, Liang Wang, Jing-jing Xiao, Long-bin Wu, Wen-hui Yang, Shi-bin Li, Wen-feng PLoS One Research Article OBJECTIVE: To evaluate surgical outcomes and prognostic factors for T4 gastric cancer treated with curative resection. METHODS: Between January 1994 and December 2008, 94 patients diagnosed with histological T4 gastric carcinoma and treated with curative resection were recruited. Patient characteristics, surgical complications, survival, and prognostic factors were analyzed. RESULTS: Postoperative morbidity and mortality were 18.1% and 2.1%, respectively. Multivariate analysis indicated lymph node metastasis (hazard ratio, 2.496; 95% confidence interval, 1.218–5.115; p = 0.012) was independent prognostic factor. CONCLUSIONS: For patients with T4 gastric cancer, lymph node metastasis was associated with poorer survival. Neoadjuvant chemotherapy or aggressive adjuvant chemotherapy after radical resection was strongly recommended for these patients. Public Library of Science 2014-09-11 /pmc/articles/PMC4161379/ /pubmed/25211331 http://dx.doi.org/10.1371/journal.pone.0107061 Text en © 2014 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Li, Ming-zhe
Deng, Liang
Wang, Jing-jing
Xiao, Long-bin
Wu, Wen-hui
Yang, Shi-bin
Li, Wen-feng
Surgical Outcomes and Prognostic Factors of T4 Gastric Cancer Patients without Distant Metastasis
title Surgical Outcomes and Prognostic Factors of T4 Gastric Cancer Patients without Distant Metastasis
title_full Surgical Outcomes and Prognostic Factors of T4 Gastric Cancer Patients without Distant Metastasis
title_fullStr Surgical Outcomes and Prognostic Factors of T4 Gastric Cancer Patients without Distant Metastasis
title_full_unstemmed Surgical Outcomes and Prognostic Factors of T4 Gastric Cancer Patients without Distant Metastasis
title_short Surgical Outcomes and Prognostic Factors of T4 Gastric Cancer Patients without Distant Metastasis
title_sort surgical outcomes and prognostic factors of t4 gastric cancer patients without distant metastasis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161379/
https://www.ncbi.nlm.nih.gov/pubmed/25211331
http://dx.doi.org/10.1371/journal.pone.0107061
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