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Retroviral Retention Activates a Syk-Dependent HemITAM in Human Tetherin

Tetherin (BST2/CD317) restricts the release of enveloped viral particles from infected cells. Coupled to this virion retention, hominid tetherins induce proinflammatory gene expression via activating NF-κB. We investigated the events initiating this tetherin-induced signaling and show that physical...

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Detalles Bibliográficos
Autores principales: Galão, Rui Pedro, Pickering, Suzanne, Curnock, Rachel, Neil, Stuart J.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161388/
https://www.ncbi.nlm.nih.gov/pubmed/25211072
http://dx.doi.org/10.1016/j.chom.2014.08.005