Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma

Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon presentation. Silencing of EWS/FLI in patient-de...

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Autores principales: Chaturvedi, Aashi, Hoffman, Laura M., Jensen, Christopher C., Lin, Yi-Chun, Grossmann, Allie H., Randall, R. Lor, Lessnick, Stephen L., Welm, Alana L., Beckerle, Mary C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161506/
https://www.ncbi.nlm.nih.gov/pubmed/25057021
http://dx.doi.org/10.1091/mbc.E14-01-0007

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