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PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

Actin filaments play an essential role in cell movement, and many posttranslational modifications regulate actin filament assembly. Here we report that prolyl hydroxylase 3 (PHD3) interacts with nonmuscle actin in human cells and catalyzes hydroxylation of actin at proline residues 307 and 322. Bloc...

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Detalles Bibliográficos
Autores principales:	Luo, Weibo, Lin, Benjamin, Wang, Yingfei, Zhong, Jun, O'Meally, Robert, Cole, Robert N., Pandey, Akhilesh, Levchenko, Andre, Semenza, Gregg L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161513/ https://www.ncbi.nlm.nih.gov/pubmed/25079693 http://dx.doi.org/10.1091/mbc.E14-02-0775

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